Study Investigating MEN1 and SDHD in Familial Carcinoid Tumors
- Conditions
- Carcinoid Neuroendocrine Cancer
- Registration Number
- NCT00672269
- Lead Sponsor
- Rutgers University
- Brief Summary
There is a high incidence among the first degree relatives of the carcinoid patients, indicating the involvement of genetic components in its initiation and pathogenesis.
- Detailed Description
This proposed pilot study will conduct detailed interviews into the medical, environmental, and family histories and to collect blood specimen to obtain DNA. The Blood specimen and DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) to rule out Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit D (SDHD), gene inactivation thought to be associated with different types of carcinoid cancer.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- Over the age of 18 years
- More than one ,member of a family with a history of biopsy confirmed carcinoid tumor
- English speaking
- Mentally and emotionally capable of answering questions
- Willing and available for study participation
- At least one other family member with carcinoid tumor
Exclusion Criteria
- If you are under the age of 18 years,
- If you are unable to understand or unable to provide informed consent,
- If you have a psychological condition (i.e. depression, anxiety disorder, substance abuse, etc.) which might cause you significant problems in dealing with test results.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mutations in MEN1 and SDHD genes 1 year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Busch Campus of Rutgers University, Human Genetics Institute
🇺🇸Piscataway, New Jersey, United States