NCT04831021
Unknown
Not Applicable
Pre- or Per-dialytic Physical Exercise : a Cardioprotective Role?
ConditionsChronic Kidney Diseases
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Kidney Diseases
- Sponsor
- University Hospital, Montpellier
- Enrollment
- 32
- Locations
- 2
- Primary Endpoint
- Change in regional myocardial function and myocardial stunning
- Last Updated
- 4 years ago
Overview
Brief Summary
This study aims at evaluating, in chronic kidney disease patients on dialysis, the effect of acute per- or pre-dialytic physical exercise on regional myocardial function and myocardial stunning, blood viscosity, arterial stiffness, variability of sinus rhythm, dialysis efficacy, inflammation, mineral and bone disorders, myokines and cardiac remodeling markers.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient aged ≥ 20 to ≤ 79 years
- •Undernourished patient according to the ARNOS score : ≥ 2
- •No medical contraindication to physical activity
- •Life expectancy greater than 6 months
- •Patient on hemodialysis for more than 3 months
- •Patients with relatively good echogenicity
Exclusion Criteria
- •Patient is participating in another Category I interventional study, or has participated in another interventional study within the past 3 months
- •The patient is in an exclusion period determined by a previous study
- •The patient is under legal protection or under guardianship or curatorship
- •It turns out to be impossible to give the patient informed information, or the patient refuses to sign the consent
- •Pregnant, parturient or breastfeeding patient
- •Patient with a contraindication to retraining
- •Patient with valvular heart disease, arteriopathy of the lower limbs stage III and IV, amputation or knee or hip prosthesis
- •Patient with musculoskeletal problems
- •Patient with severe respiratory failure
- •Paired sleep apnea syndrome
Outcomes
Primary Outcomes
Change in regional myocardial function and myocardial stunning
Time Frame: Weekly over a period of 3 weeks
Secondary Outcomes
- Change in mineral and bone metabolism markers(Weekly over a period of 3 weeks)
- Change in blood viscosity(Weekly over a period of 3 weeks)
- Change in arterial stiffness(Weekly over a period of 3 weeks)
- Change in dialysis efficacy(Weekly over a period of 3 weeks)
- Change in inflammatory markers(Weekly over a period of 3 weeks)
- Change in myokines(Weekly over a period of 3 weeks)
- Change in cardiac remodeling markers(Weekly over a period of 3 weeks)
- Change in sinus rhythm(Weekly over a period of 3 weeks)
Study Sites (2)
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