IOP Lowering Efficacy of Travoprost/Brinzolamide Fixed Combination Ophthalmic Suspension in Patients With Open-Angle Glaucoma or Ocular Hypertension
Phase 2
Completed
- Conditions
- Open-angle GlaucomaOcular Hypertension
- Registration Number
- NCT00527501
- Lead Sponsor
- Alcon Research
- Brief Summary
The purpose of this study is to compare the safety and IOP-lowering efficacy of a fixed combination of Travoprost/Brinzolamide Ophthalmuc Suspension dosed BID and QD, to TRAVATAN dosed QD and a Vehicle dosed BID in patients with open-angle glaucoma or ocular hypertension.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 136
Inclusion Criteria
- Patients 18 years of age or older of either sex and any race with diagnosed open-angle glaucoma or confirmed ocular hypertension
Exclusion Criteria
- Age (Under 18)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Mean IOP Time
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which Travoprost/Brinzolamide combination reduces IOP in open-angle glaucoma?
How does the efficacy of Travoprost/Brinzolamide fixed combination compare to standard prostaglandin analogs like TRAVATAN in ocular hypertension management?
Which biomarkers correlate with response to Travoprost/Brinzolamide fixed combination therapy in patients with primary open-angle glaucoma?
What are the potential adverse events associated with Travoprost/Brinzolamide fixed combination ophthalmic suspension and how are they managed?
Are there other fixed combination therapies for IOP reduction in open-angle glaucoma that include beta-blockers or alpha agonists alongside prostaglandin analogs?
Trial Locations
- Locations (1)
Artesia
🇺🇸Artesia, California, United States
Artesia🇺🇸Artesia, California, United States