IRCT20200517047483N1
Not yet recruiting
Phase 2
The evaluation of effectiveness of Adjunctive use of sertraline on seizure improvement in patients with drug-resistant temporal lobe epilepsy
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Shiraz University of Medical Sciences
- Enrollment
- 30
- Status
- Not yet recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Male / female (non\-pregnant female adequately protected from conception) patients, between ages 18 and 65 years
- •Patients with diagnosis of temporal lobe epilepsy
- •The patient made on the basis of clinical findings with drug\-resistant seizures defined as failure of two or more AEDs at maximal tolerated doses and one or more seizures per month
- •The patients have stable medication regimen for four weeks prior to entry
Exclusion Criteria
- •Patients with progressive neurological conditions
- •Patients with a history of non adherence for seizure diary completion or frequent clinic visits
- •Patients with a history of having any serious medical illness or major psychiatric disorder,
- •History of psychogenic nonepileptic seizures
- •History of suicidal attempt in the past five years any known
- •Pracense of contraindication for sertraline administration including: concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) and hypersensitivity to sertraline
- •Taking any other medication with significant drug interaction with sertraline
Outcomes
Primary Outcomes
Not specified
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