Exploring the Cortical Hemodynamic Variability of Four Weeks iTBS on a Healthy Participant: a Case Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Oxygenated hemoglobin (HbO) change compared to baseline
研究概览
简要总结
This study will investigate the effect of caffeine and time of day on brain excitability using excitatory brain stimulation. The investigators will recruit a healthy participant and conduct a concurrent iTBS/fNIRS protocol for 20 consecutive sessions over four weeks with or without caffeine consumption before the stimulation. Moreover, the experiment will be conducted at different times of the day (morning or afternoon)
详细描述
One healthy participant will be recruited for this study. The participants will be subjected to concurrent TBS/fNIRS, to which the iTBS will be applied on the left DLPFC and the NIRS will measure the prefrontal hemodynamic response simultaneously.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Right-handed
排除标准
- •history of epilepsy, seizures, or convulsions
- •current or past diagnosis of neurological disorders, such as head injuries, strokes, encephalitis, epilepsy, Parkinson's, or Alzheimer's
- •current or past diagnosis of psychiatric disorders, such as depression, anxiety, schizophrenia, or autism
- •with metal implants, such as a cochlear implant, neurostimulator, or cardiac pacemaker
研究组 & 干预措施
Cortical hemodynamic variability of four weeks iTBS
One healthy participant will be included in this study, which lasts for 4 weeks, 5 visits per week, involving 20 visits in total.
The participant will receive the following instructions the night before: to take 200 mg of caffeine one hour before the visit (no other caffeine intake since the wake-up) or avoid caffeine intake at all before the visit; to attend the visit in the morning or afternoon. These assignments will be randomized in a counterbalanced manner.
干预措施: Experimental time (Other)
Cortical hemodynamic variability of four weeks iTBS
One healthy participant will be included in this study, which lasts for 4 weeks, 5 visits per week, involving 20 visits in total.
The participant will receive the following instructions the night before: to take 200 mg of caffeine one hour before the visit (no other caffeine intake since the wake-up) or avoid caffeine intake at all before the visit; to attend the visit in the morning or afternoon. These assignments will be randomized in a counterbalanced manner.
干预措施: caffeine (Other)
结局指标
主要结局
Oxygenated hemoglobin (HbO) change compared to baseline
时间窗: During and post TBS-fNIRS measurement, up to 1 month
iTBS-induced HbO change in the DLPFC before, during and after stimulation
次要结局
- Deoxygenated hemoglobin (HbR) change compared to baseline(During and post TBS-fNIRS measurement, up to 1 month)
- Oxygen saturation change compared to baseline(During and post TBS-fNIRS measurement, up to 1 month)
研究者
Dr Georg Kranz
Assistant Professor
The Hong Kong Polytechnic University