Application of the Web-based Acceptance and Commitment Therapy for Depression

Not Applicable

Recruiting

• Conditions: Major Depressive Disorder
• Interventions: Device: Web-based ACT; Behavioral: Treatment as usual

• Registration Number: NCT06293781
• Lead Sponsor: Gachon University

Brief Summary

PROSPECTIVE INTERVENTION STUDY; EFFICACY OF WEB-BASED ACCEPTANCE AND COMMITMENT THERAPY

Detailed Description

Acceptance Commitment Therapy (ACT) is known to help people recover from depression by improving psychological flexibility through acceptance, defusion, self-as-context, present moment, committed action, and helping them live a values-based life. This study is a randomized controlled trial to determine if web-based ACT leads to changes in the psychological flexibility and cognitive fusion. Also, through the functional MRI study, possible treatment mechanisms by which the web-based ACT exerts will be identified.

Study Timeline

• Study Start: 2022-12-19
• Status Verified: 2024-02
• Study First Submitted: 2024-02-18
• Study First Submitted QC: 2024-02-27
• Study First Posted: 2024-03-05
• Last Update Submitted: 2024-10-13
• Last Update Posted: 2024-10-16
• Primary Completion: 2025-02-28
• Study Completion: 2025-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients who diagnosed major depressive disorder

Exclusion Criteria

• Patients who have serious medical problems, metal implants in their bodies, severe brain injury or brain disease
• Women who were pregnant or nursing
• Patients at high risk for suicide

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ACT	Treatment as usual	Web-based ACT with treatment as usual
ACT	Web-based ACT	Web-based ACT with treatment as usual
Controls	Treatment as usual	Waitlist being on the treatment as usual

Primary Outcome Measures

Name	Time	Method
Acceptance and Action Questionnaire-II	6 weeks	Psychological flexibility
Hamilton Rating Scale for Depression	6 weeks	Interviewer-rated depression scale

Secondary Outcome Measures

Name	Time	Method
Cognitive Fusion Questionnaire	6 weeks	Cognitive fusion
Beck Hopelessness Scale	6 weeks	Measuring hopelessness by the Beck Hopelessness Scale
Beck Scale for Suicide Ideation	6 weeks	Measuring suicidality
Beck Depression Inventory	6 weeks	Measuring subjective depression
Beck Anxiety Inventory	6 weeks	Measuring subjective anxiety
Functional Connectivity	6 weeks	functional connectivity of the brain during resting state
Valuing	6 weeks	Measuring one's valuing

Trial Locations

Locations (1)

Kyoung-Sae Na; 🇰🇷 Incheon, Please Incheon, Korea, Republic of