Drug to prevent lung injury secondary to COVID 19
Not Applicable
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2020/12/029613
- Lead Sponsor
- Department of anaesthesiology AIIMS Rishikesh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Age 18 years or older, with Endotracheal tube or Noninvasive ventilation in place, intubated/put on NIV yesterday or today with PaO2 to FIO2 ratio less than or equal to 300
Exclusion Criteria
1. Heparin allergy or heparin-induced thrombocytopaenia
2. APTT > 120 seconds and this is not due to anticoagulant therapy
3. Platelet count < 20 x 109 per L
4.Pulmonary bleeding, which is frank bleeding in the trachea, bronchi or lungs with repeated haemoptysis or requiring repeated suctioning
5. Uncontrolled bleeding
6. Pregnant or suspected pregnancy (Urine or serum HCG will be recorded)
7. Receiving or about to commence ECMO or HFOV
8. Death is imminent or inevitable within 24 hours
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary Outcome Measures: <br/ ><br>1.D-dimer profile [ Time Frame: Up to day 10 days. ] <br/ ><br>2.NLR ratio [Time frame up to 10 days] <br/ ><br>3.Mean daily PaO2 to FiO2 ratio [ Time Frame: 10 days ] <br/ ><br>Timepoint: Primary Outcome Measures: <br/ ><br>1.D-dimer profile [ Time Frame: Up to day 10 days. ] <br/ ><br>2.NLR ratio [Time frame up to 10 days] <br/ ><br>3.Mean daily PaO2 to FiO2 ratio [ Time Frame: 10 days ] <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Oxygenation Index, as assessed by Po2 <br/ ><br>2.Quasi-Static Lung Compliance [ Time Frame: Up to day 10] Determine the effect of nebulised heparin on Quasi-Static Lung Compliance (i.e. tidal volume/(Plateau pressure-PEEP) <br/ ><br>3.Time to separation from invasive ventilationTimepoint: day 1,3 and 10