Investigating errorless learning and semantic priming in mild cognitive impairment and mild dementia: The M-DeMi study

Completed

Conditions: cognitieve stoornis in het kader van neurodegeneratie
early dementia
mild cognitive impairment
10042258

Registration Number: NL-OMON46245

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

between 50-85 years of age
MCI (amnestic or multi-domain, CDR=0.5) or mild dementia (CDR=1)
native Dutch speaker
capable of giving informed consent

Exclusion Criteria

MCI due to vascular diseases
primary progressive aphasia
use of psychotropic medication or recreational drugs
serious head trauma or brain surgery
neurological or psychiatric disorders (other than MCI)
claustrophobia (for MRI-study)
large or ferromagnetic metal parts in the head (except for a dental wire; for MRI-study)
implanted cardiac pacemaker or neurostimulator (for MRI-study)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>EL: The effect of error frequency on memory performance in amnestic MCI and MD<br /><br>by using a novel errorless learning task in which the occurrence of errors is<br /><br>controlled compared to previous work.<br /><br>SP: To assess lexical access and executive function in semantic priming in<br /><br>amnestic MCI and MD by means of a picture-word verification task. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>EL: To compare the cognitive profile to the outcome on the EL and TEL condition.<br /><br>SP: To assess brain atrophy of frontal and temporal brain areas (using MRI) as<br /><br>well as structural connectivity of pathways connecting these regions (using<br /><br>DWI) in MCI and MD.</p><br>