Regulate Effect of Il-35 Secreting Breg Cells on Tcells and on Diseases Progression in Patients With CHB
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- IL-35+Bregs regulatory effect
研究概览
简要总结
The investigators observed the level of IL-35 secreting B regulatory (IL-35+Bregs) cells in peripheral blood cells in patients with chronic hepatitis B, and analysed the relationship between the IL-35+Bregs level and disease stage, and Th1 and Th2 cells level.
详细描述
Regulatory B cells (Bregs) are involved in the immune tolerance process through multiple pathways and Bregs are involved in the process of chronic HBV infection.
Here the investigators intended to investigate the regulating role and the mechanism of CD19+ IL-35+ cells on host T cell immune during chronic HBV infection by using in vitro cell sorting, B cell differentiation induction, Transwell cell co-culture system and other methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 17 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of chronic hepatitis B virus infection
- •17<age<70
- •Can read, understand and sign patients informed consent
排除标准
- •Co-infection with HCV,HIV,HDV etc.
- •Have malignancy
- •Have uncontrollable extra-hepatic disease
结局指标
主要结局
IL-35+Bregs regulatory effect
时间窗: enrolled day
regulatory effect of IL-35+Bregs on T cell immune
IL-35+Bregs level
时间窗: ENROLLED DAY
IL-35 secreting regulatory B cells level in patients with CHB
次要结局
- IL-35+Bregs phenotype(enrolled day)