Mechanisms of Cognitive Change

Not Applicable

Terminated

• Conditions: Psychosis

• Registration Number: NCT04103775
• Lead Sponsor: Colorado State University

Brief Summary

This study will determine whether targeted cognitive training, a low-cost and low-risk commercial cognitive remediation therapy, directly impacts therapeutic targets as well as secondary outcomes in college undergraduates. The active intervention will be compared to an active control condition (computer games). Participants will also attend CSU TILT (The Institute for Teaching and Learning) Academic Workshops.

Detailed Description

The primary goal of this project is to investigate whether commercial cognitive remediation therapy improves cognitive functioning in college undergraduates. The secondary goal is to investigate neurophysiological, cognitive, and psychosocial mechanisms of change. The investigators will compare cognitive remediation therapy to computer games. The active control condition will allow the investigators to determine whether targeted cognitive training, as an adjunct to academic skills training provided by CSU TILT, provides significant improvement over computer games alone (which is also thought to provide some value as "brain training"). Participants who agree to enroll in the study will be randomized to one of two intervention arms: cognitive remediation (CR) or active control (AC). In the CR arm, participants will complete 20 hours of targeted cognitive training, in 30-min session, 5 days per week, over 8 weeks. The AC Arm will follow the same schedule, except that participants will complete video games (e.g., pong). All participants will repeat assessments at randomly determined midpoint, as well as after the 8 weeks of training have been completed.

Study Timeline

• Study Start: 2019-09-20
• Study First Submitted: 2019-09-20
• Study First Submitted QC: 2019-09-24
• Study First Posted: 2019-09-25
• Primary Completion: 2021-01-22
• Study Completion: 2021-01-22
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-21
• Last Update Posted: 2022-09-22

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• College undergraduate;
• English fluency, and the ability to complete study requirements.

Exclusion Criteria

• College seniors (i.e., students with more than 89 credits at CSU);
• Students who are concurrently enrolled in another study investigating the efficacy or effectiveness of novel learning or cognitive development techniques (not including tutoring or other existing programs available to CSU undergraduates);
• Participants less than age 15.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
MATRICS Consensus Cognitive Battery (MCCB) Verbal Learning Subscale Scores	Three time points (1 week pre-randomization, mid-treatment [randomly selected for each participant between the 2nd and 7th week of treatment], and 1 week post-treatment) for all participants.	Change in MATRICS Consensus Cognitive Battery (MCCB) Verbal Learning Subscale. Demographically corrected T-scores (M = 50; SD = 10; higher better).

Secondary Outcome Measures

Name	Time	Method
Academic Performance	Semester data obtained yearly up to 8 years	Academic performance will be evaluated using participant grade point average improvement over the course of the study.

Trial Locations

Locations (1)

Colorado State University; 🇺🇸 Fort Collins, Colorado, United States