Comparing the Efficacy of Two Doses of Onabotulinum Toxin for the Treatment of Neurogenic Detrusor Overactivity - a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- change in detrusor pressure post-injection
研究概览
简要总结
The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively. The records of all patients treated with Onabotulinum toxin injections into the detrusor since 2000 will be evaluated. The changes in the urodynamic values after the injection of 300 units of Onabotulinum toxin will be compared with the changes after the injection of 200 units. Furthermore, the differences in urinary continence, duration between injections, side effects and complications between the two groups will be investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •neurogenic detrusor overactivity
- •spinal cord injury
- •Onabotulinum toxin injections into the detrusor from 2000-2017
排除标准
- •missing urodynamic values before or after Onabotulinum toxin injections
研究组 & 干预措施
Onabotulinum 300 units
干预措施: Injection of Onabotulinum toxin (Drug)
Onabotulinum 200 units
干预措施: Injection of Onabotulinum toxin (Drug)
结局指标
主要结局
change in detrusor pressure post-injection
时间窗: within 3 months before injection; within 2 months after injection
bladder detrusor pressure during storage phase
次要结局
- reflexive bladder volume(within 3 months before injection; within 2 months after injection)
- complications(within 2 months after injection)
- maximum bladder volume(within 3 months before injection; within 2 months after injection)
- bladder compliance(within 3 months before injection; within 2 months after injection)
- presence of urinary incontinence(within 3 months before injection; within 2 months after injection)