Comparing the Efficacy of Two Doses of Onabotulinum Toxin for the Treatment of Neurogenic Detrusor Overactivity - a Retrospective Cohort Study
Overview
- Phase
- N/A
- Intervention
- Injection of Onabotulinum toxin
- Conditions
- Neurogenic Bladder
- Sponsor
- Swiss Paraplegic Research, Nottwil
- Enrollment
- 56
- Locations
- 1
- Primary Endpoint
- change in detrusor pressure post-injection
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively. The records of all patients treated with Onabotulinum toxin injections into the detrusor since 2000 will be evaluated. The changes in the urodynamic values after the injection of 300 units of Onabotulinum toxin will be compared with the changes after the injection of 200 units. Furthermore, the differences in urinary continence, duration between injections, side effects and complications between the two groups will be investigated.
Investigators
Eligibility Criteria
Inclusion Criteria
- •neurogenic detrusor overactivity
- •spinal cord injury
- •Onabotulinum toxin injections into the detrusor from 2000-2017
Exclusion Criteria
- •missing urodynamic values before or after Onabotulinum toxin injections
Arms & Interventions
Onabotulinum 300 units
Intervention: Injection of Onabotulinum toxin
Onabotulinum 200 units
Intervention: Injection of Onabotulinum toxin
Outcomes
Primary Outcomes
change in detrusor pressure post-injection
Time Frame: within 3 months before injection; within 2 months after injection
bladder detrusor pressure during storage phase
Secondary Outcomes
- reflexive bladder volume(within 3 months before injection; within 2 months after injection)
- complications(within 2 months after injection)
- maximum bladder volume(within 3 months before injection; within 2 months after injection)
- bladder compliance(within 3 months before injection; within 2 months after injection)
- presence of urinary incontinence(within 3 months before injection; within 2 months after injection)