Robot-Mediated Impairment-Oriented and Task-Specific Training (RMIT and RMTT) on Upper Limb Post Stroke: Feasibility and Preliminary Effects on Physical Function and Quality of Life

Brief Summary

Detailed Description

1. BACKGROUND AND RATIONALE Stroke is among the top 10 causes of hospitalisation in Singapore. Approximately 630 stroke patients were transferred to our inpatient rehabilitation unit in 2021. Upper limb impairments are common after stroke and may result in loss of function, including self-care activities. Intensity of therapy is thus important for post-stroke recovery. A Cochrane overview of systematic reviews suggested that arm function can be improved by providing at least 20 hours of additional repetitive task training to patients. However, providing sufficient therapy remains a challenge due to various reasons, including manpower shortages. Robotic-mediated rehabilitation is an innovative exercise-based therapy using robotic devices that enables the implementation of highly repetitive, intensive, adaptive, and quantifiable physical training. The RATULS trial showed that neither robot-assisted training using the MIT-Manus robotic gym nor an enhanced upper limb therapy (EULT) programme based on repetitive functional task practice improved upper limb function after stroke, as compared to usual care, for patients with moderate-to-severe upper limb functional limitations. It was suggested that further research was needed to find ways to translate the improvements in upper limb impairments seen with robot-assisted therapy into upper limb function and their activities of daily living (ADLs). In a systematic review and meta-analysis on the effects of robot-assisted therapy on the upper limb, it was found that although there were improvements in strength, this was not translated to improvements in activities of daily living. Additional transition to task training (facilitated by therapists) had been added to robot-mediated impairment training (RMIT) in various studies. In a study by Hung8, robot-assisted therapy combined with occupational therapist (OT)-facilitated task specific training was found to be superior to robot-assisted therapy combined with OT-facilitated impairment-oriented training. Task-specific training consists of repetitively practising the tasks that are most relevant to the patient and their personal context, whereas impairment-oriented therapy emphasises remediation of motor deficits with a focus on single joint movements at a time. A study that investigated Reharob, a robotic device used to assist patients living with chronic stroke in performing 5 ADLs, showed that patients had significant improvements on the Fugl-Meyer Assessment - Upper Extremity (FMA-UE), Action Research Arm Test (ARAT) and Functional Independence Measure (FIM). This is the only study that has been found addressing robot-mediated task-specific training thus far (RMTT). This study aims to determine the feasibility of the application of both RMIT and RMTT utilizing the robotic device- Optimo Regen. From a review of the prevalent literature, there has been no study on the comparison of RMTT + RMIT against RMIT alone. A search for RMTT only yielded the study on Reharob, but the robot only administered RMTT and not RMIT. The preliminary effects of the intervention on physical function and quality of life will be studied. The target patients would be those with acute stroke undergoing rehabilitation in an acute inpatient rehabilitation unit. Robotic therapy can continue when they are discharged, in the outpatient clinic. According to a study on the cost of hospital care, the bulk of the hospitalisation cost went to ward charges (38.2%) with much less coming from therapy (7.3%). It thus makes sense to increase the intensity of rehabilitation so that patients may recover faster and be discharged earlier. Making therapy more available in the outpatient setting where wait times are currently long would also be advantageous. 2. HYPOTHESIS AND OBJECTIVES Hypothesis: Robot-mediated impairment-oriented and task-sepcific training improves upper limb function and is safe and feasible Objectives: To assess the feasibility of conducting robot mediated impairment-oriented training and task-specific training and to study the benefits on physical function and quality of life.

Primary Outcomes

Secondary Outcomes

• Change of FMA-UA (Fugl Meyer Assessment-Upper Arm) from baseline(baseline, 1 month and 3 months post commencement of intervention)
• Change of FMA-W/H(Fugl Meyer Assessment-Wrist/Hand) from baseline(baseline, 1 month and 3 months post commencement of intervention)
• Change of FAT (Frenchay Arm Test) from baseline(baseline, 1 month and 3 months post baseline)
• Change of FIM (Functional Independence Measure) from baseline(baseline, 1 month, 3 months post baseline)
• Change of MMT (manual muscle testing) from baseline(baseline, 1 month and 3 months post baseline)
• Change MAS (Modified Ashworth Scale) from baseline(baseline, 1 month and 3 months post baseline)
• Change of EQ-5D from baseline(baseline, 1 month and 3 months post baseline)
• Change of HADS (Hospital Anxiety and Depression Scale) from baseline(baseline, 1 month and 3 months post baseline)
• Change of patient satisfaction survey from baseline(baseline, 1 month and 3 months post baseline)
• Difference in the presence of Adverse effects(baseline, 1 month and 3 months post baseline)