Effectiveness of Adherence Therapy for Schizophrenia

Phase 1

Completed

• Conditions: Schizophreniform Disorder; Schizophrenia; Schizoaffective Disorder
• Interventions: Behavioral: Adherence therapy

• Registration Number: NCT01780116
• Lead Sponsor: The Hong Kong Polytechnic University

Brief Summary

When compared with those in the control (usual care) group, participants in the AT group are expected to demonstrate significant improvements immediately and at three, six and 12 months after completion of the intervention in: level of medication adherence, readmission rate, mental status, insight into treatment, and level of functioning.

Detailed Description

When compared with those in the control (usual care) group, participants in the AT group are expected to demonstrate significant improvements immediately and at three, six and 12 months after completion of the intervention in the following aspects:

1. level of adherence to antipsychotic medication,

2. rate and length of psychiatric hospital readmission,

3. mental status,

4. insight and attitude into illness and treatment, and

5. level of functioning.

The primary outcomes are level of antipsychotic medication adherence, re-hospitalization rates and mental status; and the patients' drug attitude will be the mediating factor of the AT.

Study Timeline

• Study First Submitted: 2013-01-29
• Study First Submitted QC: 2013-01-29
• Study First Posted: 2013-01-30
• Study Start: 2013-05
• Primary Completion: 2015-12
• Status Verified: 2016-02
• Study Completion: 2016-02
• Last Update Submitted: 2016-02-17
• Last Update Posted: 2016-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 134

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Medicaiton adherence therapy	Adherence therapy	Adherence therapy, consisting of six, 2-hour sessions over 3 months, in three phases: 1. Engaging patients: assessing needs and concerns in medication adherence; 2. Reviewing strengths and barriers and developing coping strategies; and 3. Rationalizing beliefs and concerns and preventing relapse.

Primary Outcome Measures

Name	Time	Method
re-hospitalization rate	12 months after completion of intervention	rate and length of psychiatric hospital readmission immediately, 6 months and 12 months after the completion of the intervention undertaken

Secondary Outcome Measures

Name	Time	Method
mental status	12 months follow-up	symptom severity measured at recruitment and at immediately, 6 months and 12 months after completion fo the intervention
insight into treatment	12 months follow-up	insights into illness and treatment measured at recruitment and at immediately, 6 months and 12 months after completion fo the intervention
level of medication adherence	12 months follow-up	level of adherence to antipsychotic medication measured at recruitment and at immediately, 6 months and 12 months after completion fo the intervention
functioning	12 months follow-up	level of functioning measured at recruitment and at immediately, 6 months and 12 months after completion fo the intervention

Trial Locations

Locations (2)

Kwai Chung Hospital; 🇭🇰 Kwai Chung, NT, Hong Kong

Castle Peak Hospital; 🇭🇰 Tuen Mun, NT, Hong Kong