Correlation of QT Dispersion With Myocardial Perfusion in Patients With ST Elevation Myocardial Infarction Treated by Primary Per Cutaneous Coronary Intervention
试验速览
- 阶段
- 不适用
- 入组人数
- 235
- 试验地点
- 1
- 主要终点
- Correlation of QT dispersion on 12-lead surface ECG with myocardial reperfusion
研究概览
简要总结
To correlate QT dispersion on 12-lead surface ECG with myocardial reperfusion evaluated by myocardial blush grade and Thrombolysis in myocardial infarction (TIMI) flow grades in patients with ST elevation myocardial infarction treated by Primary Per cutaneous coronary intervention
详细描述
Worldwide, coronary artery disease (CAD) is the most frequent cause of death. Over seven million people every year die from CAD, accounting for 12.8% of all deaths. Every sixth man and every seventh woman in Europe die from myocardial infarction. The in-hospital mortality of STEMI patients in the national registries of the European society of cardiology (ESC) countries varies between 6% and 14%.
ST elevation myocardial infarction (STEMI) generally results from intraluminal thrombus formation and occlusion of a ruptured or an unstable plaque .
The main goal of therapy in STEMI is to restore microvascular flow and sustain the myocardial perfusion .
Reperfusion therapy for acute myocardial infarction (AMI) is aimed at achieving prompt restoration of myocardial perfusion to maximize preservation of the electrical and mechanical integrity of the jeopardized myocardium. Percutaneous coronary intervention (PCI) has increased the rate of successful recanalization of infarct-related arteries (IRAs) to >90% .
A variety of markers including ECG and coronary angiography have been utilized to assess myocardial reperfusion .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients will be enrolled in this study if they fulfilled the criteria of acute ST elevation myocardial infarction eligible to be treated with primary Percutaneous coronary intervention
排除标准
- •Non-ST elevation myocardial infarction, prior history of myocardial infarction or surgical revascularization,
- •Electrolyte disturbance.
- •history of medications that may affect QT (anti-arrhythmic, anti-psychotic, and anti-depressant drugs),
- •patients with cardiogenic shock or needing IABP.
- •patients with previous CABG.
- •Patients with implantable devices and pacemakers.
结局指标
主要结局
Correlation of QT dispersion on 12-lead surface ECG with myocardial reperfusion
时间窗: 1 year
Use 12 lead ECG to calculate QT interval and QT dispersion comparing ECG before and after myocardial reperfusion.
Evaluation of myocardial perfusion by coronary angiography by assessing 2 parameters TIMI flow and myocardial blush grade
时间窗: 1 year
Use coronary angiography to detect myocardial blush grade and TIMI flow to assess myocardial reperfusion
次要结局
未报告次要终点
研究者
MS Roshdy
Principal Investigator
Assiut University