Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Osteoarthritis, Knee
- Sponsor
- University of Delaware
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Minimum toe clearance during walking
- Status
- Completed
- Last Updated
- 7 months ago
Overview
Brief Summary
The goal of this clinical trial is to learn about how fatigue affects the risk of falling in adults aged 55-70 years with and without knee osteoarthritis. The main questions this trial aims to answer are:
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Does fatigue increase the risk of tripping while walking? and
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Does fatigue increase the risk of falling in response to a trip while walking? Participants will
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Complete questionnaires
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Wear a device that measures physical activity for 5-7 days
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Complete a 30 minute walk on a treadmill
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Complete the following before and after the treadmill walk:
- Computer test to measure mental fatigue
- Maximal strength testing
- Balance test
Researchers will compare adults with and without knee osteoarthritis to see if fall risk in adults with knee osteoarthritis is affected more by walking activity compared to adults without knee osteoarthritis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For adults with knee osteoarthritis:
- •presence of occasional to frequent knee pain
- •knee pain that is primarily in the medial knee joint compartment
- •minimal morning joint stiffness
- •For all participants:
- •able to walk continuously for 30 minutes without an assistive device
Exclusion Criteria
- •fracture or surgery within 1 year
- •history of joint replacement
- •lower-extremity joint injections within 3 months
- •history of stroke or other neurological condition
- •cardiovascular or pulmonary conditions that limit daily activity or that preclude participation in exercise
- •history of major lower extremity or back injury or pain (except for knee osteoarthritis)
- •history of lower extremity amputation
- •use an orthotic or prosthetic to walk
- •use of beta blockers or other medications that affect fatigue
- •use of medications that affect balance
Outcomes
Primary Outcomes
Minimum toe clearance during walking
Time Frame: Beginning and end of 30 minute treadmill walk
Minimum toe clearance will be calculated from the first and last minutes of the treadmill walk using optical motion capture.
Anterior reactive stepping
Time Frame: Beginning and end of 30 minute treadmill walk
Stability margins will be calculated from a lean-release test conducted before and after the 30 minute treadmill walk
Anterior stability margins during walking
Time Frame: Beginning and end of 30 minute treadmill walk
Anterior stability margins will be calculated from the first and last minutes of the treadmill walk using optical motion capture.
Knee extensor fatigability
Time Frame: Before and after the 30 minute treadmill walk
Knee extensor fatigability will be calculated as the change in maximum knee extensor power (measured via dynamometry) pre- to post-30 minute treadmill walk