The Effects of Surgery on Plasma Vitamin C Levels and Cognitive Function in Adults Undergoing Elective Hip Surgery

Not Applicable

• Conditions: Post operative cognitive dysfunction; Plasma vitamin C depletion; Serum vitamin B12 depletion; Neurological - Other neurological disorders; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12619001212145
• Lead Sponsor: ational Institute of Integrative Medicine (NIIM)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-02
• Last Update Posted: 10 February 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Adults 65-85 yrs. scheduled for elective hip replacement orthopaedic surgery or age matched control participants on the waiting list or suffering from hip issues such as osteoarthritis or pain/discomfort.
- Exposed to spinal anaesthetic and heavy sedation during surgery
-Good comprehension of written and spoken English
-Able to give informed consent
-Must not be taking antidepressants, antipsychotics, anxiolytics, illicit drugs or any cognitive enhancing drugs
- Not taking any vitamin C or vitamin B12 supplementation post-operatively for the duration of the study

Exclusion Criteria

-Colour blindness or any other severe visual impairment
-Pregnant or lactating
-Cognitive impairment (3MS score < 79)
-History of neurological or psychiatric disorders

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive function: <br>-Swinburne University Computerised Cognitive Assessment Battery (SUCCAB) <br>-Hopkins Verbal Learning test-Revised (HVLT-R revised) <br>-Cognitive function: Symbol Digits Modalities Test (SDMT) [1-2 weeks prior to surgery <br>4-6 weeks post surgery <br>3 months post surgery <br>6 months post surgery ];Plasma vitamin C . This will be assessed by an external lab which will use a biochemical plasma assay to determine concentrations. [1-2 weeks prior to surgery <br>within 1 week post surgery <br>4-6 weeks post surgery <br>3 months post surgery <br>6 months post surgery]