Time Course of Endometrium's Gene Expression Profiles Using Endometrial Tissue and Blood Samples

Early Phase 1

Completed

• Conditions: Fertility

• Registration Number: NCT06786273
• Lead Sponsor: Inti Labs

Brief Summary

This study aims to investigate whether the expression levels of microRNA (miRNA) in endometrial tissue and blood samples at various time points after ovulation can serve as biomarkers for assessing endometrial receptivity.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-31
• Primary Completion: 2024-02-06
• Study Completion: 2024-02-06
• Status Verified: 2024-12
• Study First Submitted: 2025-01-15
• Study First Submitted QC: 2025-01-15
• Last Update Submitted: 2025-01-15
• Study First Posted: 2025-01-22
• Last Update Posted: 2025-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 62

Inclusion Criteria

• Regular menstrual cycle of 28-32 days.
• Between 25-38 years old.
• BMI between 18 to 30.
• Endogenous progesterone (P4) level of < 1 ng/mL prior to exogenous progesterone administration

Exclusion Criteria

• Suspected intrauterine abnormality.
• Women who are breastfeeding
• Have a history of pelvic inflammatory disease, reproductive tract-related diseases, sexually transmitted diseases, systemic diseases or endocrine diseases.
• History of major illness.
• Use of hormonal contraceptives or intrauterine devices in the past 3 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Primary Outcome Measures

Name	Time	Method
miRNA expression profiles	1 month	The samples collected would undergo small RNA sequencing in order to investigate the miRNA expression profiles of the patients and differences in expression profiles between the different intervention groups.

Trial Locations

Locations (1)

Lee Women's Hospital; 🇨🇳 Taichung, Taiwan