PREselection of patients at risk for COgnitive DEcline after Radiotherapy using advanced MRI (PRECODE-MRI)

Recruiting

• Conditions: benign; brain tumour; Meningioma; 10029209

• Registration Number: NL-OMON52049
• Lead Sponsor: MAASTRO clinic

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 67

Inclusion Criteria

- Meningioma WHO I, grading based on pathology or radiological features
- Age >= 18 years.
- Karnofsky Performance Score 70 or above.
- Ability to comply with the protocol, including neuropsychological testing and
imaging.
- Ability to understand the requirements of the study and to give written
informed consent, as determined by the treating physician.
- Written informed consent.

Exclusion Criteria

- Resection meningioma < 3mnd
- Age < 18 years
- Pregnancy
- Any prior cranial radiotherapy
- Any prior chemotherapy in the last 5 years
- Contra-indication for MR imaging (i.e. metal implants, claustrophobia)
- Any other serious medical condition that could interfere with follow-up.
- Severe aphasia or language barrier interfering with assessing endpoints (i.e.
completion of questionnaires or neurocognitive performance)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Correlation between the delta cognitive failure score (baseline vs 2 years) and<br /><br>radiotherapy dose in cognition related brain regions (supratentorial brain,<br /><br>hippocampus left/right and anterior/posterior, cerebellum anterior/posterior).</p><br>