The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders
- Conditions
- Respiratory Distress SyndromeTransient Tachypnea of Newborn
- Interventions
- Device: Blood Gas Sampling
- Registration Number
- NCT02813954
- Brief Summary
Amniotic fluid (AF) is a complex structure with a changing content by gestational time. AF pH can be affected by both maternal and fetal conditions such as preterm ruptures of membranes, prematurity and fetal distress. While fetal urine is the major content of AF since 20th gestational week, fetal lung liquid (FLL) also acts as a minor content. Secretion of FLL depends on chloride transport and postnatal clearance of FLL is provided by active reabsorption of sodium (Na) ions. Down-regulation of epithelial Na channels (ENaCs) and an increase of pulmonary compliance accompany to pulmonary adaptation developing at the first hours of life. Lower genomic expression of Na channels in airways is shown to be associated to respiratory distress syndrome (RDS) in preterm. Although pH and electrolyte value of AF is thought to be relevant to fetal and maternal conditions such as gestational age, antenatal steroids and preterm birth, there is no study about this topic in the literature.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 184
Accepted to participate with informed consent Normal healthy pregnancies
Congenital abnormalities Chromosomal abnormalities Blood contaminated AF Declined to participate
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Study Group Blood Gas Sampling Neonates with respiratory distress
- Primary Outcome Measures
Name Time Method The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders 8 months
- Secondary Outcome Measures
Name Time Method