Alterations in Nutrient-sensing Mechanisms May Play a Role in Symptom Generation in Patients With IBS
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Taste receptor expression was associated with symptom severity
研究概览
简要总结
Clinical data, fresh feces and intestinal mucosal tissues of patients with diarrheal IBS were collected. High performance liquid chromatography, immunohistochemistry and immunofluorescence were used to study the amino acid levels in feces of patients with IBS, the expression of taste receptors in intestinal mucosa, and the correlation between symptoms of abdominal pain and diarrhea and the expression of taste receptors, so as to obtain the conclusion that "intestinal amino acid perception abnormalities exist in patients with IBS. And correlated with clinical symptoms."
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with IBS who meet the Rome IV diagnostic criteria:
- •that is, recurrent abdominal pain, with symptoms occurring at least 1 day per week or at least 3 days per month on average in the last 3 months, combining 2 or more of the following:
- •related to defecation;
- •accompanied by changes in the frequency of bowel movements;
- •Accompanied by changes in fecal characteristics (appearance). (Symptoms appeared at least 6 months before diagnosis, and above diagnostic criteria were met in the last 3 months)
- •Age ≥18 years old.
排除标准
- •History of celiac disease and other organic intestinal diseases, metabolic diseases (thyroid dysfunction, diabetes, etc.); (2) Serious neurological, mental and psychological diseases, or accompanied by serious organ dysfunction;
- •Abdominal surgery;
- •Pregnant, possible pregnant and lactating patients;
- •History of colonoscopy in the past 1 year;
- •Declined to participate in the study.
结局指标
主要结局
Taste receptor expression was associated with symptom severity
时间窗: 1 year
The severity of symptoms was correlated with the expression of taste receptors
Association between fecal amino acid levels and symptom severity in patients
时间窗: 1year
The severity of symptoms was correlated with fecal amino acid
次要结局
未报告次要终点