Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia

Completed

• Conditions: Bronchopulmonary Dysplasia
• Interventions: Other: blood sampling

• Registration Number: NCT01644981
• Lead Sponsor: University of Zurich

Brief Summary

Serial quantitative measurements of plasma pro-endothelin-1 concentrations in very preterm infants. Comparing pro-endothelin-1 with established clinical indices of bronchopulmonary dysplasia (BPD). Hypothesis: Pulmonary-vascular remodeling in infants developing BPD is directly related to circulating pro-endothelin-1, which therefore serves as surrogate marker of BPD.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2012-05
• Study First Submitted: 2012-07-17
• Study First Submitted QC: 2012-07-18
• Study First Posted: 2012-07-19
• Primary Completion: 2013-09
• Study Completion: 2013-12
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-09
• Last Update Posted: 2016-05-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

Not provided

Read More

Exclusion Criteria

Not provided

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
VLBW infants	blood sampling	-

Primary Outcome Measures

Name	Time	Method
duration of supplemental oxygen requirement	36 weeks postmenstrual age	Bronchopulmonary dysplasia

Secondary Outcome Measures

Name	Time	Method
duration of respiratory pressure support	during hospitalisation	respiratory pressure support either mechanical and/or nCPAP (days)

Trial Locations

Locations (1)

University Hospital Zurich, Division of Neonatology; 🇨🇭 Zurich, ZH, Switzerland