FimasaRtan-basEd BP Targets After Drug SwitcHing

Completed

Brief Summary: The recent hypertension clinical practice guidelines published by American College of Cardiology (ACC) and American Heart Association (AHA) reduced the target BP to 130/80 mmHg, indicating the needs for more aggressive efforts in hypertension treatment. However, studies in Koreans must be preceded before applying such new overseas guidelines; thus, this study has been designed to establish clinical materials reflecting treatment setting in Korea. In this study, patients with uncontrolled hypertension whose antihypertensive regimens are changed to ARB-based therapy (ARB monotherapy or ARB-containing combination therapy) will be followed to assess the treatment trend, treatment effect, and risk of cardiovascular disease.

Detailed Description: This study will be performed in patients with blood pressure (BP) uncontrolled by existing antihypertensive drugs (including ARB) among hypertensive patients visiting outpatient clinic of medical institutions in Korea. The study enrollment number will be assigned to the subjects who provide a written consent to the use of personal information and meet the inclusion/exclusion criteria. Follow-up will be conducted for 12 weeks in total and prespecified study related data will be collected in the case report form.

Recruitment & Eligibility

Inclusion Criteria

Provided written consent to the use of personal information after receiving the explanation of the objective, methodology, etc. of this clinical study
Male or female adults ≥ 19 years who are diagnosed with essential hypertension
Receiving outpatient treatment at the time of study enrollment
Patients with hypertension uncontrolled by existing antihypertensive drugs (including ARB) whose antihypertensive regimens decided and scheduled to be changed to ARB monotherapy or ARB-containing combination therapy (the result of the arm with a higher mean BP [systolic BP preferred] when measured twice with at least a 2-minute interval in both arms at the medical office on the study enrollment date, will become the reference)
- Definition of uncontrolled hypertension: Target BP (SBP <140 mmHg and DBP <90 mmHg) not achieved even after the treatment using the existing antihypertensive drugs for 4 weeks or longer

Exclusion Criteria

Patients who were hospitalized or are scheduled to be hospitalized 4 weeks before or after the study enrollment date
Patients with suspected or confirmed secondary hypertension
Pregnant or breast-feeding women
Patients who received investigational product within 12 weeks or are scheduled to participate in another clinical study while participating in this study
Patients who are determined inappropriate for participating in the study by investigators for other reasons

Primary Outcome Measures

Name	Time	Method
Percentage of Patients With Controlled Blood Pressure (<140/90 mmHg)	Week 12 after the treatment regimen change	Percentage of patients who attain the target blood pressure (BP) (\<140(SBP)/90(DBP) mmHg) at Week 12 after the treatment regimen change

Secondary Outcome Measures

Name	Time	Method
Percentage of Patients With Controlled BP According to 2018 KSH Guideline	Week 12 after the treatment regimen change	Percentage of patients who attain the target BP specified in 2018 hypertension clinical practice guidelines\* suggested by Korean Society of Hypertension at Week 12 after the treatment regimen change. \2018 hypertension clinical practice guidelines : Target BP \<140(SBP)/90(DBP) mmHg. For patients meeting any of the conditions listed below, each corresponding criterion will be applied. Patients with cardiovascular disease :\<130/80 mmHg * Patients with diabetes : \<140/85 mmHg * Patients with diabetes accompanying cardiovascular disease :\<130/80 mmHg * Patients with chronic kidney disease accompanying albuminuria: \<130/80 mmHg
Percentage of Patients With Controlled BP According to 2017 ACC/AHA Guideline	Week 12 after the treatment regimen change	Percentage of patients who attain the target BP(\<130(SBP)/80(DBP)mmHg) specified in 2017 clinical practice guidelines for hypertension suggested by American College of Cardiology(ACC)/American Heart Association(AHA) at Week 12 after the treatment regimen change
Prcentage of Patients With Controlled BP According to Investigator's Target BP	Week 12 after the treatment regimen change	Percentage of patients who attain the investigator's target BP\* at Week 12 after the treatment regimen change. \*Investigator's target BP: Target BP for each patient set by the investigator at baseline.