Assessment of Executive Functions After Covid-19

Completed

• Conditions: Covid19; Cognitive Impairment

• Registration Number: NCT04771624
• Lead Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

Brief Summary

As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.

Detailed Description

Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.

Study Timeline

• Study Start: 2020-10-30
• Study First Submitted: 2021-02-22
• Study First Submitted QC: 2021-02-24
• Study First Posted: 2021-02-25
• Primary Completion: 2021-04-30
• Status Verified: 2021-11
• Study Completion: 2021-11-01
• Last Update Submitted: 2021-11-02
• Last Update Posted: 2021-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

Covid-19 patients:

• Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago
• Asymptomatic at the moment
• Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection

Healthy subjects:

• Not having any of Covid-19 symptoms at the testing time point
• Not having any general medical, neurological or psychiatric condition

Exclusion Criteria

Covid-19 patients:

• Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago
• Having any symptom of acute phase of Covid-19
• Having any other general medical, neurlogical or psychiatric contidions

Healthy subjects:

• Having any of Covid-19 symptoms at the testing time point
• Having any general medical, neurological or psychiatric condition

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neuropsychological test scores	Up to 90 days	Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects

Secondary Outcome Measures

Name	Time	Method
Severity of the disease	Up to 90 days	Neuropsychological test score changes according to the disease severity of Covid-19 patients

Trial Locations

Locations (1)

Sağlık Bilimleri Üniversitesi Gazi Yaşargil Training and Research Hospital; 🇹🇷 Diyarbakır, Turkey