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Clinical Trials/NCT07757971
NCT07757971Not yet recruitingNot Applicable

Association of Second-to-Fourth Digit Ratio (2D:4D) With Trait Anxiety and Occupational Stress Among Anesthesiology Residents: A Cross Sectional Observational Study

Ain Shams University0 sites116 target enrollmentStarted: September 15, 2026Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
116
Primary Endpoint
Anxiety score

Study Overview

Brief Summary

Anesthesiologists are exposed to substantial occupational stress, making their psychological well-being essential for both personal health and optimal patient care. Early identification of mental health disorders among healthcare professionals is important for improving well-being and maintaining healthcare quality.

Detailed Description

Although anesthesia residency is associated with considerable psychological stress, residents differ in how they respond to these challenges. While some develop psychological distress, others continue to perform effectively despite the demanding environment. These individuals, often described as "resilient" or "stress resistant," demonstrate successful adaptation to stress. The mechanisms underlying these individual differences remain incompletely understood. As with many aspects of psychological functioning, responses to stress are influenced by the combined effects of genetic predisposition and environmental experiences throughout life.

Among the biological markers investigated in recent years, the second-to-fourth digit (2D:4D) ratio has attracted considerable scientific interest because of its reported associations with a wide range of physical, behavioral, and psychological traits.

Study Design

Study Type
Observational
Observational Model
Ecologic Or Community
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
20 Years to 35 Years (Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Any anesthesiologists who voluntarily agreed to participate in the study.
  • •Age: 20-35 years
  • •Both genders

Exclusion Criteria

  • •Incomplete questionnaires and/or irrelevant responses.
  • •Injuries to the 2nd or 4th digits,
  • •Unclear or inaccurate digit photocopy,
  • •If the participant is a twin
  • •Cumulative leave (e.g., maternity/sick leave) exceeding 6 months during the study period;
  • •Pre-existing diagnosis of psychiatric disorders prior to the study

Outcomes

Primary Outcomes

Anxiety score

Time Frame: Baseline (single assessment)

Anxiety severity measured using the Penn State Worry Questionnaire (PSWQ). The PSWQ is a 16-item validated measure of the tendency toward excessive, uncontrollable worry, the cognitive hallmark of Generalized Anxiety Disorder. The association between anxiety score and digit measurement will be evaluated. Total scores range from 16 to 80, with higher scores indicating greater worry severity. A score ≥45 is commonly used as a clinical cutoff in research settings, with ≥60 strongly associated with Generalized Anxiety Disorder criteria.

Secondary Outcomes

  • Demographic data(Baseline (single assessment))

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Raham Hasan Mostafa, MD

Professor of Anesthesia ,pain and intensive care

Ain Shams University

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