A Phase 1, Single Ascending Dose Study of the Safety and Pharmacokinetics of TT30 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Overview
- Phase
- Phase 1
- Intervention
- ALXN1102
- Conditions
- Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Sponsor
- Alexion Pharmaceuticals, Inc.
- Enrollment
- 10
- Locations
- 5
- Primary Endpoint
- Assess the safety and tolerability of a single dose of TT30.
- Status
- Terminated
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of this research study is to understand the safety, pharmacokinetics and pharmacodynamics of a single dose of TT30 (ALXN1102 and ALXN1103 formulations) when given IV (through a vein) or SC (under the skin) to patients with PNH.
Detailed Description
This is an open-label, single-dose, dose-escalation study to assess the safety, tolerability, PK, PD, and immunogenicity of TT30 given as an IV infusion and as a SC injection in subjects with PNH or evidence of circulating PNH cells. Eligible subjects with PNH will be vaccinated with meningococcal vaccine at least two weeks prior to dosing (if not previously vaccinated or if revaccination is required). On study day 1, the subject will receive the single dose of TT30 as an IV infusion over 60 minutes or as a SC injection, and be followed with additional study evaluations over the next 59 days.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Individuals at least 18 years of age with a diagnosis of PNH \& vaccination against meningococcus.
Exclusion Criteria
- •Abnormal renal or liver function
- •History of meningococcal disease
- •History of Guillain-Barre syndrome
- •Known infection with HIV or Hepatitis B or C
- •History of thrombotic events
Arms & Interventions
TT30 (ALXN1102 Formulation)
IV: 0.1, 0.3, and 1.0 mg/kg
Intervention: ALXN1102
TT30 (ALXN1103 Formulation)
IV: 3.0, 6.0, and 10.0 mg/kg SC: 1.0 and 3.0 mg/kg
Intervention: ALXN1103
Outcomes
Primary Outcomes
Assess the safety and tolerability of a single dose of TT30.
Time Frame: 60 days
Safety and tolerability will be evaluated in all subjects by physical exam, vital signs, ECGs, laboratory changes over time, adverse events, and antibody development.
Secondary Outcomes
- Characterize PK, PD and immunogenicity of a single dose of TT30.(60 days)