The Effect of Different Types of Anemia on HbA1c Levels in Non-Diabetics
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Mean HbA1c Level
研究概览
简要总结
The goal of this observational study is to learn about the effects of different types of anemia on HbA1c test results in non-diabetic adults who have anemia but do not have diabetes. The main question it aims to answer is:
- Do different types of anemia (iron deficiency, vitamin B12/folate deficiency, thalassemia, and anemia of chronic illness) cause HbA1c levels to be falsely high or low in people without diabetes?
详细描述
Type of the study:
- Observational cross-sectional study.
Site of the Study :
- Sohag University Hospital and hematology or endocrinology outpatient clinic.
Study population:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Adult participants aged 18 years and above.
- •Non-diabetic individuals, defined as:
- •Fasting plasma glucose < 126 mg/dL and/or
- •HbA1c < 6.5%, with no prior diagnosis of diabetes mellitus.
- •Individuals diagnosed with anemia based on WHO criteria:
- •Hemoglobin < 13 g/dL in males
- •Hemoglobin < 12 g/dL in female
- •Patients with hemolytic anemia including thalassemia ( thalassemia trait and intermediate ) , sickle cell ( trait and disease ).
- •Patients with confirmed specific types of anemia, based on laboratory evaluation:
- •Iron deficiency anemia
- •Vitamin B12 deficiency anemia
- •Folate deficiency anemia
- •Anemia of chronic diseases
排除标准
- •Known cases of diabetes mellitus or prediabetes.
- •Recent blood transfusion within the last 3 months.
- •Use of medications known to affect HbA1c levels
- •Acute illness or infection at the time of enrollment.
- •Pregnant women
- •Hematological malignancies
研究组 & 干预措施
Non anemic non-diabetics
Anemic non-diabetics
结局指标
主要结局
Mean HbA1c Level
时间窗: At the time of enrollment
Comparison of mean glycosylated hemoglobin (HbA1c) levels, measured as a percentage (%), between non-diabetic adults diagnosed with specific types of anemia (iron deficiency anemia, vitamin B12 deficiency anemia, folate deficiency anemia, and anemia of chronic disease) and a non-anemic control group.
次要结局
- Correlation Between HbA1c and Hemoglobin Concentration(At the time of enrollment)
- Correlation Between HbA1c and Mean Corpuscular Volume (MCV)(At the time of enrollment)
- Correlation Between HbA1c and Mean Corpuscular Hemoglobin (MCH)(At the time of enrollment)
- Correlation Between HbA1c and Mean Corpuscular Hemoglobin Concentration (MCHC)(At the time of enrollment)
- Difference in HbA1c Across Anemia Severity Grades(At the time of enrollment)
- Correlation Between HbA1c and Serum Ferritin(At the time of enrollment)
- Correlation Between HbA1c and Serum Iron(At the time of enrollment)
- Correlation Between HbA1c and Total Iron-Binding Capacity (TIBC)(At the time of enrollment)
研究者
Mohamed Safwat Saad
Resident doctor in Internal Medicine Department
Sohag University