Role of PET/MRI in Head and Neck Cancer

Completed

• Conditions: Head and Neck Cancer; Benign Neoplasm; Malignant Neoplasm
• Interventions: Radiation: Radiotherapy

• Registration Number: NCT04360993
• Lead Sponsor: University of Pecs

Brief Summary

Study aim was to investigate the diagnostic role of Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) in head and neck cancer.

Detailed Description

This study was assessed the role of Diffusion weighted imaging (DWI) in discriminating between benign and malignant lesions in Head and neck cancer as well as studying the relationship between glucose metabolism (18F-FDG) and Apparent diffusion coefficient (ADC) for better tumor assessment.

Study Timeline

• Study Start: 2016-04-12
• Primary Completion: 2019-08-09
• Study Completion: 2020-01-22
• Study First Submitted: 2020-04-17
• Study First Submitted QC: 2020-04-22
• Study First Posted: 2020-04-24
• Status Verified: 2020-12
• Last Update Submitted: 2020-12-24
• Last Update Posted: 2020-12-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• Proved Head and neck cancer
• Underwent PET/CT and PET/MRI
• Lymph nodes due to primary Head and neck cancer.

For healthy subject:

• No previous history of malignancy.
• no inflammation or infection in the neck region.
• lymph node size <10mm.

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Exclusion Criteria

• patients treated before by radiotherapy / chemoradiotherapy
• patients underwent surgery
• artifacts

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients underwent PET/CT & PET/MRI	Radiotherapy	Patients with head and neck cancer were underwent PET/CT and PET/MRI for staging, assessment and follow up

Primary Outcome Measures

Name	Time	Method
Difference in Apparent diffusion coefficient value between benign and malignant lesions	Baseline	Apparent diffusion coefficient (ADC) was measured from benign and malignant lymph nodes by drawing region of interest (ROI) on the most homogeneous and most solid part in the target lymph node. Higher ADC value in Benign lymph node means that there are more water molecules movement inside the lymph node, more water molecules movement resulting in higher Apparent diffusion coefficient value. in malignant nodes and due to more tumor tissue, the result is to have lower water molecules motion so, lower ADC value.