A comparitive study between two drugs esmolol and dexmedetomidine for inducing regulated hypotension in functional endoscopic sinus surgery
Phase 2
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/02/031034
- Lead Sponsor
- Department of Anaesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Randomly selected patients admitted in ENT ward with nasal pathology belonging to American Society of Anaesthesiologists (ASA)status I and II, aged between 18 and 55 years of either sex and willing to give written consent will be included in the study
Exclusion Criteria
Patient refusal
Any known hypersensitivity or contraindication to esmolol, dexmedetomidine,nitroglycerine,fentanyl
Uncontrolled hypertension
Cardiovascular diseases including conduction disturbances
Renal or hepatic dysfunction
Coagulation disorders
Patients on medications affecting coagulation system
Pregnant or lactating mothers
Paediatric patients
Patients on calcium channel blockers
Patients with history of significant neurological, psychiatric or neuromuscular disorders
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intraoperative blood lossTimepoint: After induction of anaesthesia, every 15mins for first hour and every 30 mins thereafter.
- Secondary Outcome Measures
Name Time Method Duration of surgery, duration of controlled hypotension (min), number of patients treated with fentanyl (%), min fentanyl dose per patient (mcg), number of patients treated with nitroglycerine,min nitroglycerine used per patient (mg), hemodynamics intraoperatively,oxygen saturation (spo2) during controlled hypotension and any other adverse effects during study periodTimepoint: Hemodynamic monitoring will be recorded preoperatively, after induction of anaesthesia, after intubation,every 15 mins for the first hour and every 30 mins thereafter and after extubation