Streptococcus Pneumonia: Effects of PCV13 on Pneumococcal Carriage
- Conditions
- Nasopharyngeal Carriage of S. Pneumoniae
- Registration Number
- NCT01109108
- Lead Sponsor
- Boston Medical Center
- Brief Summary
The specific aim is to evaluate the impact of PCV13 as administered in the pediatric primary care clinic at Boston medical center on the serotype specific carriage of Streptococcus pneumoniae in children \< 5.
Specifically the investigators will measure the decline in vaccine serotypes, the proportion of children receiving vaccine required to achieve 50% reduction in serotype specific carriage and the correlation between immunogenicity of the specific serotypes and decline in carriage. The study has been extended to complete 5 years of surveillance to determine the new SP serotype distribution at the time presumably a new equilibrium has been achieved.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 9000
- children < 5 years of age receiving care at Primary Care center at BMC and as many parent(s) as willing to participate
- children with facial malformations making NP sampling unacceptable
- children in foster care
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Nasopharngeal Colonization With PCV13 S. Pneumoniae Study years 1-5 Proportion of PCV13 serotypes among n=1851 children colonized with any S. pneumoniae
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Pediatric Primary Care, Boston Medical Center
🇺🇸Boston, Massachusetts, United States