Testing the Effect of Speeded Anomia Therapy in Patients With Chronic Post-stroke Aphasia: a Cross-over Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Speeded anomia therapy effect in reaction time
研究概览
简要总结
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).
详细描述
The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production.
This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Native English speakers
- •Age 18 years or above
- •Stroke (any type) greater than 12 months post onset
- •No history of neurological disorders / psychiatric disorders
- •Normal or corrected-to-normal hearing & vision
- •Able to give informed consent
- •Currently not receiving Speech & Language therapy
- •Minimal repetition skills (>40% on an immediate word repetition test)
- •Evidence of naming difficulties (<90% in Boston Naming Test - Goodglass et al., 1983)
排除标准
- •Non-native English speakers
- •Less than 18 years old
- •Stroke less than 12 months post onset
- •History of neurological disorders / psychiatric disorders
- •Uncorrected hearing & vision
- •Unable to give informed consent
- •Currently receiving Speech & Language therapy
- •Insufficient repetition skills (<40% on an immediate word repetition test)
- •Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)
结局指标
主要结局
Speeded anomia therapy effect in reaction time
时间窗: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Change in reaction time in single-item picture naming
Speeded anomia therapy effect in accuracy
时间窗: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Change in accuracy in single-item picture naming
Generalisation to connected speech
时间窗: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Change in word retrieval in composite picture description. Participants will be asked to describe composite pictures (from the "Where's Waldo/Wally?" publications).
次要结局
- Generalisation to story-telling connected speech(Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10))
研究者
Matthew A. Lambon Ralph
Professor
University of Cambridge