Speeded Anomia Treatment in Chronic Post-stroke Aphasia
- Conditions
- Aphasia
- Interventions
- Behavioral: Speeded anomia therapy
- Registration Number
- NCT05512884
- Lead Sponsor
- University of Cambridge
- Brief Summary
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).
- Detailed Description
The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production.
This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
- Native English speakers
- Age 18 years or above
- Stroke (any type) greater than 12 months post onset
- No history of neurological disorders / psychiatric disorders
- Normal or corrected-to-normal hearing & vision
- Able to give informed consent
- Currently not receiving Speech & Language therapy
- Minimal repetition skills (>40% on an immediate word repetition test)
- Evidence of naming difficulties (<90% in Boston Naming Test - Goodglass et al., 1983)
- Non-native English speakers
- Less than 18 years old
- Stroke less than 12 months post onset
- History of neurological disorders / psychiatric disorders
- Uncorrected hearing & vision
- Unable to give informed consent
- Currently receiving Speech & Language therapy
- Insufficient repetition skills (<40% on an immediate word repetition test)
- Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Speeded anomia therapy Speeded anomia therapy 21h of anomia therapy
- Primary Outcome Measures
Name Time Method Speeded anomia therapy effect in reaction time Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10) Change in reaction time in single-item picture naming
Speeded anomia therapy effect in accuracy Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10) Change in accuracy in single-item picture naming
Generalisation to connected speech Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10) Change in word retrieval in composite picture description. Participants will be asked to describe composite pictures (from the "Where's Waldo/Wally?" publications).
- Secondary Outcome Measures
Name Time Method Generalisation to story-telling connected speech Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10) Change in narrative speech production. Participants will be asked to narrate the Cinderella story. A checklist with some of the most frequently used nouns (data obtained from AphasiaBank database) will be used.
Trial Locations
- Locations (1)
MRC Cognition & Brain Sciences Unit
🇬🇧Cambridge, United Kingdom