Correlation Between Quality of Life and Severity of Parkinson's Disease by Assessing an Optimal Cut-off Point on the Parkinson's Disease Questionnaire (PDQ-39) as Related to the Hoehn & Yahr (H&Y) Scale
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 513
- Locations
- 1
- Primary Endpoint
- Parkinson's Disease questionnaire (PDQ-39)
Study Overview
Brief Summary
This study aim to evaluate the correlation between Quality of Life (QoL) and severity of Parkinson's Disease (PD) by assessing the presence of an optimal cut-off point on the Parkinson's disease questionnaire (PDQ-39) as related to the Hoehn & Yahr (H&Y) scale in a cohort of Italian adults with PD.
A multicenter, cross-sectional study was performed in central and northern Italy. This study was conducted on a cohort of consecutive individuals at three neurologic outpatient clinics. All participants were evaluated with the PDQ-39, and the severity of PD was recorded according to the H&Y scale by a neurologist. Receiver operating characteristic (ROC) curves and coordinates of the curve, which were visually inspected, were used to find cut-off points with optimal sensitivity and specificity. These were in turn used to determine the optimal PDQ-39 cut-off score for identifying disease severity according to H&Y stages.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 50 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age > 50 but < 90 years,
- •H&Y stages I, II, III, and IV,
- •a mini-mental state examination > 22 points,
- •a minimum level of five years of education.
Exclusion Criteria
- •Individuals with emotional or psychiatric problems (as determined by clinical screening)
Outcomes
Primary Outcomes
Parkinson's Disease questionnaire (PDQ-39)
Time Frame: at admission to the neurologic outpatient clinics
quality of life
Hoehn & Yahr (H&Y)
Time Frame: at admission to the neurologic outpatient clinics
severity of Parkinson's disease
Secondary Outcomes
No secondary outcomes reported
Investigators
Giovanni Galeoto
Department of Public Health and Infection disease, Sapienza University of Rome
R.O.M.A. - Rehabilitation & Outcome Measures Assessment