Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?

Completed

• Conditions: Dizziness
• Interventions: Other: LFTs

• Registration Number: NCT02733549
• Lead Sponsor: Adiyaman University Research Hospital

Brief Summary

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of liver function tests for patients with SOD in the ED, and a cost analysis of liver function tests.

Detailed Description

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. The diagnosis of acute liver dysfunction (ALD) can usually be made by initial symptoms, physical examination, and biochemical tests, including liver function tests (LFTs) with high sensitivity and specificity. LFTs include albumin, bilirubin, coagulation factors (Activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR)), and liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), and y-glutamyl transpeptidase (GGT), which are marker of hepatic damage. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of LFTs for patients with SOD in the ED, and a cost analysis of LFTs.

Study Timeline

• Study Start: 2012-09
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Study First Submitted: 2016-03-27
• Status Verified: 2016-04
• Study First Submitted QC: 2016-04-08
• Last Update Submitted: 2016-04-09
• Study First Posted: 2016-04-11
• Last Update Posted: 2016-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 198

Inclusion Criteria

1. Adult patients who were experiencing sudden onset dizziness of unknown etiology for the first time were included in the study

Exclusion Criteria

1. Patients with a history of chronic diseases such as any liver disease,diabetes mellitus, hypertension,congestive heart failure, hepatitis B or C infection
2. Patients with any central dizziness attacks
3. Patients with hemodynamically unstable and emesis;
4. Patients receiving drugs that could affect liver function tests, such as, acetaminophen, antibiotics, oral contraceptives, antihypertensive drugs (e.g., angiotensinconverting enzyme inhibitors), or hormones (e.g.,estrogen)
5. Patients who was experienced dizziness with systemic diseases
6. Patients with any neurological disorders
7. Patient who do not want to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patient	LFTs	Patients with sudden onset dizziness (SOD) analysed LFTs
control	LFTs	The control group with 98 healthy volunteer analysed LFTs

Primary Outcome Measures

Name	Time	Method
LFTs serum levels by biochemical method ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and Platelet count (PC)	5 months	The serum levels of LFTs will obtained by the laboratory analysis of blood samples of each participant.

Secondary Outcome Measures

Name	Time	Method
The cost calculation for the LFTs	5 months	The cost for the LFTs will be calculated with financial data in invoices which will obtained from the hospital invoicing service.

Trial Locations

Locations (1)

Adiyaman University Research Hospital; 🇹🇷 Adiyaman, Central, Turkey