Temporal Changes in Parasternal Intercostal Muscle Thickening as a Possible Biomarker for Successful Weaning From Mechanical Ventilation: a Prospective Observational Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Cairo University
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Accuracy of change in PIC-TF in predicting successful weaning from mechanical ventilation
Study Overview
Brief Summary
optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences
Detailed Description
Several parameters were proposed to assess proper weaning time including diaphragmatic ultrasound and extra-diaghragmatic muscles. previous research concluded an ability of parasternal intercostal (PIC) thickening to predict weaning outcomes. researchers of current study assumed that temporal changes in PIC thickening would provide greater ability to predict weaning outcomes
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •- Mechanically ventilated for 24 hours or more ready for weaning
Exclusion Criteria
- •Refusal Tracheostomized Inability to obtain ultrasound views patients with neuromuscular disease
Outcomes
Primary Outcomes
Accuracy of change in PIC-TF in predicting successful weaning from mechanical ventilation
Time Frame: At baseline and 30 minutes after initiation of spontaneous breathing trial
percentage of change in PIC TF in predicting weaning outcome
Secondary Outcomes
- Accuracy of change in PIC-TF to predict reintubation(At baseline and 30 minutes after initiation of spontaneous breathing trial)
Investigators
Mina Adolf Helmy
Lecturer of anesthesia and critical care
Cairo University