Schistosomiasis in Senegal

Not Applicable

Active, not recruiting

• Conditions: Schistosomiasis
• Interventions: Other: Bottom-up intervention

• Registration Number: NCT03187366
• Lead Sponsor: University of Notre Dame

Brief Summary

Schistosomiasis is a flatworm transmitted from freshwater snails to humans in the tropics. In addition to this infectious disease, tropical developing countries are faced with malnutrition. We propose to alter pesticide and compost use to reduce schistosomiasis and maintain or even improve crop production.

Detailed Description

We propose two types of manipulations. Bottom-up manipulations will affect snail resources, whereas top-down manipulations will affect snail predators. For the bottom-up manipulations, we will clear schistosoma infections in school children, then remove the primary habitat for snails, the submerged macrophyte Ceratophyllum demersum (with proper unmanipulated controls), compost it, apply it to crops, and then quantify reinfection rates and crop yields. The second bottom-up manipulation will be to clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk herbicides, or eliminate herbicides and fertilizers), and then quantify reinfection rates and crop yields. Farmers will be compensated for any loss in yields. For the top-down manipulations, every village will receive prawns that depredate snails. We will clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk insecticides that don't kill prawns, or eliminate insecticides), and then quantify reinfection rates and crop yields. Farmers will be compensated for any loss in yields.

Study Timeline

• Study Start: 2017-01-02
• Study First Submitted: 2017-06-12
• Study First Submitted QC: 2017-06-12
• Study First Posted: 2017-06-14
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-22
• Primary Completion: 2025-09
• Study Completion: 2025-09

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1477

Inclusion Criteria

• School age children

Exclusion Criteria

• Non-school age children

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
No agrochemicals	Bottom-up intervention	Villages that eliminate agrochemicals
Low risk	Bottom-up intervention	Villages shifted to low risk pesticides that don't kill prawns

Primary Outcome Measures

Name	Time	Method
Schistosomiasis reinfection rate	One year	Schistosomiasis reinfection rate

Secondary Outcome Measures

Name	Time	Method
Crop yields	One year	Crop yields

Trial Locations

Locations (1)

Espoir Pour La Santé (EPLS); 🇸🇳 Saint-Louis, Senegal