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Clinical Trials/ISRCTN16597586
ISRCTN16597586
Completed
未知

Investigating whether the magnitude of postoperative inflammatory and insulin resistant responses is related to body composition and physiological function of skeletal muscle and adipose tissue: a randomised controlled trial

niversity of Nottingham (UK)0 sites32 target enrollmentNovember 25, 2011
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ConditionsTopic: Generic Health Relevance and Cross Cutting ThemesSubtopic: Generic Health Relevance (all Subtopics)Disease: SurgeryInjury, Occupational Diseases, PoisoningComplications of surgical and medical care

Overview

Phase
未知
Intervention
Not specified
Conditions
Topic: Generic Health Relevance and Cross Cutting Themes
Sponsor
niversity of Nottingham (UK)
Enrollment
32
Status
Completed
Last Updated
7 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

2018 results in https://www.ncbi.nlm.nih.gov/pubmed/29454501

Registry
who.int
Start Date
November 25, 2011
End Date
September 28, 2013
Last Updated
7 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversity of Nottingham (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Age 18\-75 years
  • •2\. Correct body mass index (BMI) and waist circumference criteria (Obese group ? BMI \>\=30 or waist circumference \> 94 cm in men and \> 80 cm in women. Non obese group ? BMI 18\.5\-25\) or
  • •3\. Waist circumference (\<\=94cm in men and \<\=80 cm in women)
  • •4\. Due to undergo elective major abdominal surgery
  • •5\. American Society of Anaesthesiologists physical status (ASA IIII)
  • •6\. Caucasian patients
  • •7\. Able to give informed consent and comply with study protocol
  • •Target Gender: Male \& Female; Upper Age Limit 75 years ; Lower Age Limit 18 years

Exclusion Criteria

  • •1\. History of significant preoperative weight loss (\>10% over preceding 3 months )
  • •2\. Clinical history of pulmonary aspiration
  • •3\. Known gastrooesophageal reflux disease (GORD) or hiatus hernia
  • •4\. History of difficult intubation or conditions leading to the latter such as: previous neck radiotherapy/rheumatoid arthritis/presence of thyroid goitre
  • •5\. Metabolic disorders (e.g. diabetes mellitus, thyroid disease, Cushing?s Syndrome)
  • •6\. Simultaneous participation in another clinical study or involvement in a clinical study within the preceding 3 months
  • •6\. Patients with suspicion of alcohol/drug abuse
  • •7\. Pregnancy

Outcomes

Primary Outcomes

Not specified

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