Investigating whether the magnitude of postoperative inflammatory and insulin resistant responses is related to body composition and physiological function of skeletal muscle and adipose tissue: a randomised controlled trial

niversity of Nottingham (UK)0 个研究点目标入组 32 人开始时间: 2011年11月25日最近更新: 2018年6月18日

适应症

试验速览

•1. Age 18-75 years
•2. Correct body mass index (BMI) and waist circumference criteria (Obese group ? BMI >=30 or waist circumference > 94 cm in men and > 80 cm in women. Non obese group ? BMI 18.5-25) or
•3. Waist circumference (<=94cm in men and <=80 cm in women)
•4. Due to undergo elective major abdominal surgery
•5. American Society of Anaesthesiologists physical status (ASA IIII)
•6. Caucasian patients
•7. Able to give informed consent and comply with study protocol
•Target Gender: Male & Female; Upper Age Limit 75 years ; Lower Age Limit 18 years

•1. History of significant preoperative weight loss (>10% over preceding 3 months )
•2. Clinical history of pulmonary aspiration
•3. Known gastrooesophageal reflux disease (GORD) or hiatus hernia
•4. History of difficult intubation or conditions leading to the latter such as: previous neck radiotherapy/rheumatoid arthritis/presence of thyroid goitre
•5. Metabolic disorders (e.g. diabetes mellitus, thyroid disease, Cushing?s Syndrome)
•6. Simultaneous participation in another clinical study or involvement in a clinical study within the preceding 3 months
•6. Patients with suspicion of alcohol/drug abuse
•7. Pregnancy

发起方

niversity of Nottingham (UK)