Impact of Aerobic Exercise Training on Sympathetically Mediated Vasoconstriction and Vascular Function in Individuals With Essential Hypertension (IMPROVEH)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Copenhagen
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Blood pressure
Study Overview
Brief Summary
Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 35 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Sedentary men and women age 35 - 65 years
- •Resting blood pressure >140/90 mmHg or Resting blood pressure <140/90 mmHg
- •Essential hypertension
- •Non or exclusively antihypertensive medication
Exclusion Criteria
- •Hypertensive condition other than essential hypertension
- •Other chronical diseases
- •Excess alcohol intake or drug abuse
Arms & Interventions
Hypertensive
Men and women in age-group 35-65 years Resting blood pressure of >140/90 mmHg non or only anti-hypertensive medication
Intervention: Training (Other)
Control
Men and women in age-group 35-65 years Resting blood pressure of <140/90 mmHg no medication
Intervention: Training (Other)
Outcomes
Primary Outcomes
Blood pressure
Time Frame: Before and after 8 weeks of training
Changes in systolic and diastolic blood pressure
Secondary Outcomes
- Rheology(Before and after 8 weeks of training)
- Endothelial cell characterization(Before and after 8 weeks of training)
- Skeletal muscle characterization(Before and after 8 weeks of training)
- Mitochondrial function in endothelial cells(Before and after 8 weeks of training)
- Platelet reactivity(Before and after 8 weeks of training)
- Body Composition(Before and after 8 weeks of training)
- Pannexin channel function assessed in vivo(Before and after 8 weeks of training)
- Pannexin channel distribution in skeletal muscle tissue(Before and after 8 weeks of training)
- Sympathetic activity(Before and after 8 weeks of training)
- Reactive oxygen species formation in in endothelial cells(Before and after 8 weeks of training)
- Maximal oxygen uptake(Before and after 8 weeks of training)
- Vascular function(Before and after 8 weeks of training)
Investigators
Ylva Hellsten
Professor
University of Copenhagen