NCT03778489已完成不适用
Impact of Aerobic Exercise Training on Sympathetically Mediated Vasoconstriction and Vascular Function in Individuals With Essential Hypertension (IMPROVEH)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Blood pressure
研究概览
简要总结
Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sedentary men and women age 35 - 65 years
- •Resting blood pressure >140/90 mmHg or Resting blood pressure <140/90 mmHg
- •Essential hypertension
- •Non or exclusively antihypertensive medication
排除标准
- •Hypertensive condition other than essential hypertension
- •Other chronical diseases
- •Excess alcohol intake or drug abuse
结局指标
主要结局
Blood pressure
时间窗: Before and after 8 weeks of training
Changes in systolic and diastolic blood pressure
次要结局
- Mitochondrial function in endothelial cells(Before and after 8 weeks of training)
- Platelet reactivity(Before and after 8 weeks of training)
- Body Composition(Before and after 8 weeks of training)
- Pannexin channel function assessed in vivo(Before and after 8 weeks of training)
- Pannexin channel distribution in skeletal muscle tissue(Before and after 8 weeks of training)
- Sympathetic activity(Before and after 8 weeks of training)
- Reactive oxygen species formation in in endothelial cells(Before and after 8 weeks of training)
- Maximal oxygen uptake(Before and after 8 weeks of training)
- Vascular function(Before and after 8 weeks of training)
- Rheology(Before and after 8 weeks of training)
- Endothelial cell characterization(Before and after 8 weeks of training)
- Skeletal muscle characterization(Before and after 8 weeks of training)
研究者
Ylva Hellsten
Professor
University of Copenhagen
研究点 (2)
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