NL-OMON34978已完成不适用
Percutaneous coronary intervention versus conservative treatment in patients with stable angina pectoris (EUREGIO AP study): Can magnetic resonance perfusion imaging improve the triage of patients with stable angina? - EUREGIO-AP-study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Cardiologie
- 入组人数
- 400
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •All patients with stable angina pectoris and >=70% stenosis in at least one epicardial coronary artery (proximal or mid segment) can be included. Stable angina pectoris is defined as Canadian Cardiovascular Society [CCS] class I-III or medically stabilized class IV angina. Patients must be able to give informed consent.
排除标准
- •- Age < 18 years.
- •- Pregnancy.
- •- Significant systemic hypertension (BP > 200/100mmHg) unresponsive to medical therapy.;Other cardiac pathology:
- •- Atrial fibrillation.
- •- Cardiogenic shock.
- •- Previous myocardial infarction, defined as: (UNL = upper normal limit)
- •a) New Q wave at any time.
- •b) Spontaneous, total CK/CK-MB >= 1.5 x UNL or troponin >= 2 x UNL.
- •- Congestive heart failure NYHA class >=III.
- •- Previous CABG or PCI.
- •- Unstable angina pectoris (persistent CCS class IV despite medical treatment).
- •- Left main (>= 50%) or 3 vessel disease or markedly positive treadmill test during stage 1 of the Bruce protocol.
- •- Ejection fraction < 30 %
- •- Concomitant valvular disease likely to require surgery or affect prognosis during follow up.
- •- Congenital or primary cardiac muscle disease likely to affect prognosis during follow-up.
- •- Resuscitated out-of-hospital sudden death or symptomatic sustained or non-sustained ventricular tachycardia.
- •Contraindications to MR imaging:
- •- Noncompatible metallic implant (vascular clip, neurostimulator, cochlear implant).
- •- Pacemaker or ICD.
- •- Claustrophobia.
- •- Body weight >130 kg. ;Contraindication to MRI contrastagent (Gadolinium):
- •- Renal failure (estimated GFR <= 30 mL/min) or chronic kidney disease stage 4 & 5. ;Contraindication to adenosine side effects:
- •- AV-block (2nd or 3rd degree).
- •- Severe asthma.
- •- COPD Gold IV.;To exclude patients with chest pain from non-cardiac origin, CT-angiography or coronary angiography will be performed to confirm the presence of significant coronary artery disease (>=70% stenosis).
研究者
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