a comparative clinical study of erandbeejadi gutika pippalyadi gana kashaya and ruksha pottali sweda in the management of amavata

Phase 1/2

Not yet recruiting

• Conditions: Rheumatoid arthritis with rheumatoid factor, unspecified. Ayurveda Condition: AMAVATAH,

• Registration Number: CTRI/2023/02/049968
• Lead Sponsor: Department of Kayachikitsa Shri Narayan Prasad Awasthi Govt. Ayurved College Raipur CHHATTISGARH

Brief Summary

In the 7th century, acharya Madhava emphasizesthat it is a systemic disorder involving digestive and metabolic mechanisms.in text described the main symptoms of Amavata clearly.They can be classified under the following headings: -Pratyatma Lakshana:-Sandhi Shoola, Sandhi Shotha, and Stabdhata.In modern science, It is correlated to rheumatoid arthritis (RA). It is a chronic autoimmuneinflammatory systemic disease. In this, the body’s immune system attacks its tissue, which affects synovial joints with extra-articular manifestations. Inthis bilateral, peripheral joints are involved symmetrically.  Primary symptoms of RA are joint inflammation, pain, loss offunction, and eventual joint destruction and deformity. For the present study, on amavata as shaman therapy, the medicine I choose is a suitable natural product that will make itpossible for patients to live a high quality of life along with reducing the specificsymptoms of pain, swelling & stiffness. These medicines have properties of deepan,pachan,shulahar & shothahar without any side effects in our textes. Considering themagnitude of amavata, I am doing a clinical & comparative study of ErandbeejadiGutika, Pippalayadi Gana Kashaya & Ruksha pottali Sweda in the management ofAmavata.

the volunteers will be informed about the study protocol. willing participants will be randomly selected as per the coin method.  clinical research format will be prepared and validated before the study approval will be taken from the IEC of the NPA government Ayurved college and hospital, Raipur C.G.and CTRI registration will be done. after selection, each participant will be tasted individually and selected according to the selection criteria.

Sixty patientsof Amavata will be selected from Kayachikitsa OPD and IPD Shrihri NPA government Ayurved college andhospital, Raipur C.G. The case selection was in regards to age, sex, occupation, and socio‑economic conditions. Both acute and chronic phases of Amavatapatients were taken for the study, following the ACR criteria for diagnosing RA in modern medicine and the clinical features of Amavata described inMadhava Nidana. The present studyis a single-center, open-labeled randomized (coin method) clinical trial. A total of 60clinically diagnosed and registered patients of Amavata were divided randomlyby coin method into two groups. Eachgroup will have 30 patients. Group A: 30clinically diagnosed patients of Amavata will be treated with erandbeejadigutika two tablets(each 500 mg) fourtimes in a day with lukewarm water before meal for 90 days along with modifiedruksha sweda.Group B: 30clinically diagnosed patients of Amavata were treated with pippalyadi ganakashaya 50 ml two times n a day aspatient Agni Bala aftAgni Balafor 90 days along with  modified ruksha sweda.modified ruksha pottali sweda :-Ingredient:- Baluka (50%) +Shunthi+Yava+Saindhav Lavan+Methi+Shatpushpa(50%).

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-03
• Last Update Posted: 2023-02-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• it is based on Clinical signs and symptoms mentioned in ayurvedic and modern classics, especially pain swelling, and stiffness.
• Health Assessment Questionnaire for RA Visual Analog Scale (VAS) WOMAC Index.

Exclusion Criteria

• 1.Patients below 18 years and above 60 years of age will not be taken.
• 2.Patients who develop a secondary complication of RA e.g. pleuro-pericardial disease.
• severely damaged joint with bedridden patients and severe crippling deformities.
• 3.Patients having neoplasm of the spine, gout, ankylosing spondylitis, traumatic arthritis, and pyogenic osteomyelitis.
• 4.Patients suffering from paralysis, Liver cirrhosis, Liver failure, Hepatocellular or any carcinoma, and Ascites.
• 5.Patients having associated cardiac disease, pulmonary tuberculosis, uncontrolled diabetes mellitus, malignant hypertension, renal function impairment, etc.
• 6.Pregnant and lactating mother.
• 7.Patients who are taken steroids.
• 8.Other joint disorders like Gout, Osteoarthritis.
• The patient mentioned above who is suffering from any severe disease will come under the category of exclusion.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
reduce the symptoms of amavata especially pain,swelling and stiffness(rheumatoid arthritis)	reduce the symptoms of amavata in 8 weeks

Secondary Outcome Measures

Name	Time	Method
improve the quality of life	90 days

Trial Locations

Locations (1)

Shri Narayan Prasad Awasthi Government Ayurved College Raipur CHHATTISGARH; 🇮🇳 Raipur, CHHATTISGARH, India

Shri Narayan Prasad Awasthi Government Ayurved College Raipur CHHATTISGARH

🇮🇳Raipur, CHHATTISGARH, India

Dr Byomesh Upadhyay

Principal investigator

7566819731

Upadhyaybyomesh@gmail.com