CTRI/2023/08/056104尚未招募Unknown
Diagnostic accuracy of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis and correlation with outcomes in patients with tubercular meningitis, spinal tubercular arachnoiditis-An ambispective cohort study
All India Institute of Medical Sciences, New Delhi0 个研究点目标入组 0 人开始时间: 待定最近更新:
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- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
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研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Inclusion Criteria :Patients attending OPD or are admitted in Neurology ward/Geriatric Medicine ward/General medicine ward or Medical Oncology ward with chronic meningitis diagnosed on the basis of composite clinical criteria, imaging criteria as well as natural history of the illness
- •1)Atleast 14 years of age of all sexes
- •2)Chronic meningitis : Case definition
- •a.Headache with or without fever, nuchal stiffness and systemic symptoms
- •b. CSF suggestive of meningitis Pleocytosis ( >20 cells per μL) with lymphocyte predominance ( >50%) OR Protein concentration greater than age-specific normal value; especially >1·0 g/L OR Glucose concentration less than 60% of concentration in blood OR MRI suggestive of meningeal enhancement on contrast enhanced T1 sequences AND
- •c. Deemed by the treating physician that the syndrome is consistent with chronic meningitis
- •3. Patients who are positive for antibodies to HIV and pregnant females will also be included.
- •4. Willing to undergo periodic assessment clinically and with MRI as per clinical condition demands.
- •Etiologies: AFB on CSF staining; India ink stain or CSF cryptococcal antigen positivity on lateral flow assays or culture positivity for cryptococcosis, cultures, PCR and other microbiologic tests suggestive of chronic bacterial or fungal infections such as brucellosis, nocardiosis, melioidosis, syphilis, aspergillosis, histoplasmosis etc, CSF cytology positivity for leukematous, lymphomatous or carcinomatous cells, aseptic chronic meningitis in the setting of connective tissue diseases such as SLE, Sjogrenâ??s syndrome, Behcetâ??s disease etc.
- •Exclusion criteria for prospective arm
- •? Not willing to provide consent
排除标准
- •Not willing to provide consent
研究者
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