Prevalence of Brain Health Versus Neurodegeneration in Former Professional Football Players
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- David Okonkwo, MD, PhD
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Rates of Brain Health versus Cognitive Impairment
Overview
Brief Summary
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 29 Years to 59 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: Cognitive/Neuropsychological Testing (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: Vestibular/Ocular-Motor Testing (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: Sleep Evaluation (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: MRI, High-Resolution (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: Health & Physical Exam (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: Health & Physical Exam (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: Physical Function (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: Blood Testing and Biomarker Analysis (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: Applanation Tonometry (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: PET brain imaging (Diagnostic Test)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: [C-11]6-OH-BTA-1 (Drug)
Former Professional Football Players
Former professional football players who played in at least 3 professional seasons, with at least 3 games each season.
Intervention: [F-18]AV-1451 (Drug)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: Cognitive/Neuropsychological Testing (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: Vestibular/Ocular-Motor Testing (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: Sleep Evaluation (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: MRI, High-Resolution (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: Physical Function (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: Blood Testing and Biomarker Analysis (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: Applanation Tonometry (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: PET brain imaging (Diagnostic Test)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: [C-11]6-OH-BTA-1 (Drug)
Control Groups
Friends and brothers of the Former Professional Football Player group.
Intervention: [F-18]AV-1451 (Drug)
Outcomes
Primary Outcomes
Rates of Brain Health versus Cognitive Impairment
Time Frame: 1-week
The diagnosis of cognitive impairment is based on the ADRC National Alzheimer's Coordinating Center (NACC) criteria for mild cognitive impairment. This criteria is adjudicated following a comprehensive neuropsychological exam, and includes: (1) Self- or informant-reported cognitive complaint, (2) Objective cognitive impairment, (3) Preserved independence in functional abilities, and (4) No dementia.
Secondary Outcomes
- Clinical Syndromes of Neurodegeneration(1-week)
Investigators
David Okonkwo, MD, PhD
Professor
University of Pittsburgh