Assessment of Platelet-derived GARP in Atherosclerotic Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- GARP Expression in Platelets
Study Overview
Brief Summary
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in tissue from patients with atherosclerosis, the carotid or femoral plaque representing a good source of residual material adequate for research purpose. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Older than 18 years
- •Able to give informed consent
- •Undergoing carotid or femoral endarterectomy
Exclusion Criteria
- •Younger than 18 years
- •Unable to give informed consent
Arms & Interventions
Endarterectomy population
This group includes patients with significant atherosclerotic burden justifying a surgical intervention of carotid or femoral endarterectomy.
Intervention: Tissue sample and data collection (Other)
Outcomes
Primary Outcomes
GARP Expression in Platelets
Time Frame: Throughout the entire study, approximately during 3 years
The number of cells/area expressing the GARP protein will be assessed
Secondary Outcomes
- GARP Expression T Regulating Cells(Throughout the entire study, approximately during 3 years)
- GARP Expression General(Throughout the entire study, approximately during 3 years)