Assessment of Platelet-derived GARP in Atherosclerotic Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- GARP Expression in Platelets
研究概览
简要总结
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in tissue from patients with atherosclerosis, the carotid or femoral plaque representing a good source of residual material adequate for research purpose. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 18 years
- •Able to give informed consent
- •Undergoing carotid or femoral endarterectomy
排除标准
- •Younger than 18 years
- •Unable to give informed consent
研究组 & 干预措施
Endarterectomy population
This group includes patients with significant atherosclerotic burden justifying a surgical intervention of carotid or femoral endarterectomy.
干预措施: Tissue sample and data collection (Other)
结局指标
主要结局
GARP Expression in Platelets
时间窗: Throughout the entire study, approximately during 3 years
The number of cells/area expressing the GARP protein will be assessed
次要结局
- GARP Expression T Regulating Cells(Throughout the entire study, approximately during 3 years)
- GARP Expression General(Throughout the entire study, approximately during 3 years)