Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,500
- 试验地点
- 1
- 主要终点
- Prevalence of intrinsic capacity decline at baseline (robust / pre-frail)
研究概览
简要总结
This study evaluates the implementation of a structured community-based pathway to screen, risk stratify, and prevent decline in intrinsic capacity (IC) among adults aged 60 years and above in Singapore. Using the World Health Organization (WHO) Integrated Care for Older People (ICOPE) framework and digital screening tools, participants will undergo IC domain screening in community settings. Individuals identified with early decline will receive targeted multidomain interventions and/or referral to primary or specialist care as indicated. Participants will be followed longitudinally to assess feasibility, uptake, functional trajectories, and implementation outcomes.
详细描述
Population ageing is associated with progressive decline in intrinsic capacity (IC), defined by WHO as the composite of physical and mental capacities across mobility, cognition, vitality (nutrition), psychological, and sensory domains. Early detection of IC decline enables preventive, person-centred interventions to delay frailty, disability, and long-term care dependency.
The SPICE study operationalises the WHO ICOPE framework within Singapore's community ageing ecosystem through a coordinated hub-and-spoke model linking:Community screening platforms (e.g., Active Ageing Centres), Community Health Posts, Regional health system services and other social service organisations.
The pathway consists of:
Step 1: IC Screening
- Screening using WHO ICOPE Monitor tools. Step 2: In-Depth Assessment
- Participants screening positive for decline undergo structured assessment of affected domains.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •pre-frail or robust older adults who can provide consent and follow instructions
排除标准
- •frail or with terminal illness
研究组 & 干预措施
Screen and Prevent Intrinsic Capacity Decline in Elders (SPICE)
Community-dwelling adults robust or pre-frail aged 60 years and above who undergo WHO ICOPE-aligned digital intrinsic capacity screening, structured risk stratification, personalised multidomain community-based interventions, and longitudinal follow-up.
干预措施: ICOPE-Based Digital Intrinsic Capacity Monitoring and Triggered Follow-up (SPICE Pathway) (Other)
结局指标
主要结局
Prevalence of intrinsic capacity decline at baseline (robust / pre-frail)
时间窗: Baseline
Proportion of participants (restricted to robust and pre-frail at baseline) with ≥1 impaired IC domain on screening; and proportion impaired by each domain (mobility, cognition, vitality, psychological, sensory).
Uptake of recommended actions (implementation effectiveness)
时间窗: Up to 3 months post-recommendation
Proportion of participants who initiate at least one recommended action within a defined window after screening/plan (e.g., enrolment in a prescribed community programme, completion of recommended assessment, or attendance at a referred service).
次要结局
- Frailty progression(over 12 months follow up)
- Identification of (a set of) biomarkers of aging(30 months)
- Feasibility and reach(30 months)
- Change in intrinsic capacity and function over time(12 months from enrolment)
- Cost per participant screened(3 years)
- Number of participants with at least one unscheduled emergency department visit or hospital admission(12 months)
- Implementation outcomes assessed using RE-AIM framework(3 years)