Exercise and Overnight Motor Sequence Task

Not Applicable

Completed

• Conditions: Schizophrenia and Related Disorders; Psychotic Disorders
• Interventions: Other: Exercise; Other: Non-exercise

• Registration Number: NCT03800368
• Lead Sponsor: The University of Hong Kong

Brief Summary

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12-21
• Primary Completion: 2017-09-01
• Study Completion: 2017-09-01
• Status Verified: 2019-01
• Study First Submitted: 2019-01-03
• Study First Submitted QC: 2019-01-08
• Last Update Submitted: 2019-01-08
• Study First Posted: 2019-01-11
• Last Update Posted: 2019-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• Aged from 18 to 55
• Based on the SCID diagnosed to have schizophrenia and related psychotic disorders
• Ability to understand the nature of the study and to give written informed consent

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Exclusion Criteria

• Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders
• Comorbid substance dependence
• Unstable psychotic symptoms
• A history of brain trauma or organic brain disease
• Known history of intellectual disability or special school attendance
• Answered one or more "yes" in the PAR-Q and without doctors approval for exercise

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-endurance group	Exercise	This group of subjects will receive 2-3 sessions of high-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will interchange between the aerobic and anaerobic state.
Low-endurance group	Exercise	This group of subjects will receive 2-3 sessions of low-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will maintain at an aerobic level.
Psycho-education	Non-exercise	This group of subjects will receive 2-3 sessions of psycho-education class per week, for a total of 12 weeks. The content of the class includes non-exercise related psycho-education content to participants (e.g., food hygiene, psychological well being, food nutrition, etc).

Primary Outcome Measures

Name	Time	Method
The sleep-dependent procedural memory consolidation after 12 weeks of intervention	12-week Follow-up	Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment.

Secondary Outcome Measures

Name	Time	Method
The verbal memory consolidation after 12 weeks of intervention	12-week Follow-up	Tested by comparing the logical memory task performance between the three groups during the 12-week follow-up assessment
The sleep quality after 12 weeks of intervention	12-week Follow-up	Measured by using the Pittsburgh Sleep Quality Index (PSQI) and compare the differences between the three groups during the 12-week follow-up assessment
The insomnia severity after 12 weeks of intervention	12-week Follow-up	Measured by using the Insomnia Severity Index (ISI) and compare the differences between the three groups during the 12-week follow-up assessment
The attention performance after 12 weeks of intervention	12-week Follow-up	Measured by using the cancellation task performance and compare between the three groups during the 12-week follow-up assessment