12-week Aerobic-Anaerobic Transition Exercise Intervention and Overnight Sleep-dependent Procedural Memory Consolidation in Patients With Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 主要终点
- The sleep-dependent procedural memory consolidation after 12 weeks of intervention
研究概览
简要总结
The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged from 18 to 55
- •Based on the SCID diagnosed to have schizophrenia and related psychotic disorders
- •Ability to understand the nature of the study and to give written informed consent
排除标准
- •Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders
- •Comorbid substance dependence
- •Unstable psychotic symptoms
- •A history of brain trauma or organic brain disease
- •Known history of intellectual disability or special school attendance
- •Answered one or more "yes" in the PAR-Q and without doctors approval for exercise
研究组 & 干预措施
High-endurance group
This group of subjects will receive 2-3 sessions of high-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will interchange between the aerobic and anaerobic state.
干预措施: Exercise (Other)
Low-endurance group
This group of subjects will receive 2-3 sessions of low-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will maintain at an aerobic level.
干预措施: Exercise (Other)
Psycho-education
This group of subjects will receive 2-3 sessions of psycho-education class per week, for a total of 12 weeks. The content of the class includes non-exercise related psycho-education content to participants (e.g., food hygiene, psychological well being, food nutrition, etc).
干预措施: Non-exercise (Other)
结局指标
主要结局
The sleep-dependent procedural memory consolidation after 12 weeks of intervention
时间窗: 12-week Follow-up
Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment.
次要结局
- The verbal memory consolidation after 12 weeks of intervention(12-week Follow-up)
- The sleep quality after 12 weeks of intervention(12-week Follow-up)
- The insomnia severity after 12 weeks of intervention(12-week Follow-up)
- The attention performance after 12 weeks of intervention(12-week Follow-up)
研究者
Dr. Lincoln Lik-Hang Lo
Postdoctoral Fellow
The University of Hong Kong