Does Muscle Mass At Intensive Care Unit Admission Determine Mortality: the Memo Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- 30-day mortality
研究概览
简要总结
This retrospective monocentric study aims to investigate whether a low muscle mass at ICU admission and its loss over the ICU stay predicts mortality, and in what proportion we can counteract it by nutritional support.
详细描述
The study hypothesis is that a low muscle mass at ICU admission, measured at the level of L3 on CT scans performed for clinical routine, and its change over the ICU stay predict the prognosis of the patient, especially the 30-day mortality, that it may at least be partly counteracted by nutritional support and that it is related with higher ICU and hospital costs.
The objectives of this retrospective study are to determine:
- the link between baseline body composition at ICU admission and outcomes, such as 30-day, ICU and hospital mortality and LOS, and infections. If this is confirmed, we aim to evaluate the added values of body composition to ICU severity scores to predict 30-day mortality
- the link between baseline body composition vs. other locations to predict outcomes
- the impact of body composition changes on the afore-mentioned outcomes. If this is confirmed, we aim to evaluate the added value of changes in body composition to changes in ICU severity scores to predict 30-day mortality
- the impact of nutritional support on body composition changes
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Associations of baseline body composition with clinical outcomes:
- •Adults ≥ 18 yrs, hospitalized in the ICU of the HUG between January 1st 2010 and December 31st 2022 and Abdominal, or thoraco-abdominal CT scan measured 48 hours before to 96 hours after ICU admission in the HUG
- •Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers:
- •Identical as for the associations of baseline body composition with clinical outcomes and At least one additional CT performed during the hospital stay
排除标准
- •Associations of baseline body composition with clinical outcomes:
- •CT scans of low quality or CT scans performed outside of the HUG or Presence of a documented refusal
- •Associations of body composition changes with clinical outcomes, nutritional support or medico-economic paratemers:
- •Additionnally: oral nutrition, because we cannot assess the quantity and composition of oral intakes retrospectively
结局指标
主要结局
30-day mortality
时间窗: 30-day mortality between January 1st 2010 and December 31st 2022.
Association between skeletal muscle index (SMI) at the L3 vertebra level (psoas + abdominal wall muscles + paraspinal muscles), measured from 48 hours before to 96 hours after ICU admission, with 30-day mortality.
次要结局
- Association of body composition changes with outcomes(Day 30)
- Association of body composition changes with nutritional support(Day 30)
- Association of muscle loss with medico-economical parameters(Day 30)
- Association of baseline body composition at ICU admission with other outcomes(30-day)
- Association of baseline SMI at the L3 vertebra level vs. other locations to predict outcomes(Day 1 to day 30)
研究者
Genton Graf Laurence
Prof.
University Hospital, Geneva