Oestradiol Pre-treatment in an Ultrashort Flare GnRH Agonist/GnRH Antagonist Protocol in Poor Responders Undergoing IVF
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Live birth rate
研究概览
简要总结
To evaluate the effect of oestradiol pre-treatment in a combined ultrashort flare GnRH agonist /GnRH antagonist protocol
详细描述
The combined ultrashort flare GnRH agonist /GnRH antagonist protocol during COH cycle resulted in a significantly higher clinical pregnancy rate in patients with poor embryo quality, with repeated IVF failures and in poor responders. This is a protocol combining the effect of the microdose flare on endogenous FSH release with the benefit of an immediate LH suppression of the GnRH antagonist.
A major disadvantage of the use of a GnRH antagonist protocol is the limitation for programming cycles, as the drugs administration is started on day 2 of the menstrual cycle and is strictly followed until the hCG criteria are met.
The purpose of the study is to perform oestradiol pre-treatment with the combined ultrashort flare GnRH agonist /GnRH antagonist protocol aiming to
- better programme an antagonist cycle and
- improve the IVF outcome parameters, from the production of more follicles / oocytes up to the rise in live birth rates.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with poor or no response in previous COH for IVF cycles
- •Patients with AMH < 1 and/or FSH >12
- •Poor quality of embryos in previous cycles
- •Age of patients up to 44 years
排除标准
- •Patients with normal ovarian reserve
- •Patients with sonographically detected hydrosalpinges
- •Presence of intramural fibroid distorting the endometrial cavity or submucous myoma or Asherman's syndrome
- •Women with thrombofilia disorders
结局指标
主要结局
Live birth rate
时间窗: 2 years
Clinical pregnancy rate
时间窗: 2 years
次要结局
- Ectopic pregnancy(2 years)
- Miscarriage rate(2 years)
- Number of oocytes retrieved(2 years)
- Top embryo quality at day 2(2 years)
- Biochemical pregnancy(2 years)
研究者
Siristatidis Charalampos, MD, PhD
Assistant Professor in Obstetrics and Gynecology/Assisted Reproduction
National and Kapodistrian University of Athens