Saliva and serum concentrations of fluconazole in childre

• Conditions: 10017528; (invasive) Candida infection; yeast infection

• Registration Number: NL-OMON31910
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

Included are children on oral (with of without enteral tube) or intravenous fluconazole treatment.

Exclusion Criteria

Excluded are children from whom it is impossible to get saliva ,or who have, due to their condition, such a serious mucositis of their oral cavity that saliva is mixed with blood, are excluded.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-pharmacokinetics of fluconazole in saliva and serum in children and neonates<br /><br>-fluconazole saliva/serum concentration ratio in children and neonates.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-Efficacy of fluconazole treatment, as measured by negative<br /><br>(surveillance-)cultures.<br /><br>-Does fluconazole reach sufficient levels in the gastrointestinal tract when<br /><br>the administration route is intravenous</p><br>