Randomized Cross-over Trial to Investigate the Effect of Inosine on Human Energy Expenditure
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- resting energy expenditure after Inosine
Study Overview
Brief Summary
Investigators want to test whether the intake of the nucleoside inosine increases the human energy expenditure. Inosine occurs as a metabolic intermediate in the human body and is sometimes taken as a dietary supplement by athletes.
For this purpose, investigators will measure the basal metabolic rate by indirect calorimetry. Study participants will then take inosine dissolved in water or placebo and energy expenditure will be assessed again.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy male volunteers
- •BMI between 18-27 kg/m2
- •Age between 18 and 40 years
Exclusion Criteria
- •Chronic concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),
- •Known or suspected non-compliance, drug or alcohol abuse,
- •Inability to follow the procedures of the study
- •Participation in another study with investigational drug within the 30 days preceding and during the present study,
- •Previous enrolment into the current study,
- •Enrolment of the investigator, his/her family members, employees and other dependent persons,
- •Thyroid disorders
Arms & Interventions
Water
250 ml of tap water only
Intervention: Placebo (Other)
Inosine
2 grams of inosine dissolved in 250 ml of tap water
Intervention: Inosine (Dietary Supplement)
Outcomes
Primary Outcomes
resting energy expenditure after Inosine
Time Frame: one hour after oral intake of inosine
resting energy expenditure (REE) assessed by indirect calorimetry after oral intake of two grams of inosine as compared to placebo
Secondary Outcomes
- Change in energy expenditure(one hour after oral intake of inosine)
- Change in Respiratory Quotient(one hour after oral intake of inosine)
- Serum inosine level(0 hours, 1 hour, 2 hours)