Maastricht IBS Cohort: Phenotypical and genotypical characterization of patients with Irritable Bowel Syndrome

Recruiting

Conditions: Irritable bowel syndrome
10017977

Registration Number: NL-OMON50635

Lead Sponsor: Interne Geneeskunde

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 1400

Inclusion Criteria

IBS patients:
1) IBS will be diagnosed according to the Rome III criteria:
Recurrent abdominal pain or discomfort at least 3 days per month in the last 3
months associated with 2 or more of the following:
* Improvement with defecation
* Onset associated with a change in frequency of stool
* Onset associated with a change in form (appearance) of stool
2) Based on the medical history and previous examination, no other causes for
the abdominal complaints can be defined. , Healthy controls:
1) Age between 18 and 75 years

Exclusion Criteria

IBS patients:
1) Abdominal surgery, except for uncomplicated appendectomy, laparoscopic
cholecystectomy or hysterectomy. , Healthy controls:
1) Gastrointestinal disorders (current or in medical history) or current
gastrointestinal complaints.
2) Abdominal surgery, except for uncomplicated appendectomy, laparoscopic
cholecystectomy or hysterectomy.
3) Use of medication that can influence gastrointestinal motility or perception
(like loperamide, butylscopolamine, psylliumsead (metamucil), duspatal,
metoclopramide, domperidon, erytromycine and serotonin reuptake inhibitors),
for at least 3 months before tests.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Hypothesis:<br /><br>Subgroups of IBS patients can be identified according to phenotypical and<br /><br>genotypical patterns<br /><br><br /><br>Primary objective:<br /><br>- To set up a cohort of at least 1000 IBS patients and 400 healthy controls in<br /><br>order to identify different patient subgroups according to phenotypical and<br /><br>genotypical patterns</p><br>

Secondary Outcome Measures